Centrum and Hyperreflexia - a phase IV clinical study of FDA data

Summary:

Hyperreflexia is reported as a side effect among people who take Centrum (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e), especially for people who are male, 50-59 old, also take Elavil, and have Back pain.

The phase IV clinical study analyzes which people have Hyperreflexia when taking Centrum. It is created by eHealthMe based on reports of 33,642 people who have side effects when taking Centrum from the FDA, and is updated regularly.

What is Centrum?

Centrum has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 34,683 Centrum users. Check the latest studies of Centrum.

What is Hyperreflexia?

Hyperreflexia (overactive or over responsive reflexes) is found to be associated with 474 drugs and 644 conditions by eHealthMe. Check the latest studies of Hyperreflexia.

On Jan, 29, 2026

33,642 people reported to have side effects when taking Centrum.
Among them, 14 people (0.04%) have Hyperreflexia.

Among these 14 people:

What is the gender of people who have Hyperreflexia when taking Centrum? *

female: 50 %
male: 50 %

What is the age of people who have Hyperreflexia when taking Centrum? *

What are other drugs people take besides Centrum? *

What are other side effects people have besides Hyperreflexia? *

Gait Disturbance: 13 people, 92.86%
Nausea (feeling of having an urge to vomit): 13 people, 92.86%
Anaemia (lack of blood): 13 people, 92.86%
Dizziness: 13 people, 92.86%
Weight Decreased: 12 people, 85.71%
Muscle Spasms (muscle contraction): 11 people, 78.57%
Headache (pain in head): 10 people, 71.43%
Depression: 7 people, 50.00%
Nephrosclerosis (hardening of the kidney due to renovascular disease): 7 people, 50.00%
Disability: 7 people, 50.00%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 7 people, 50.00%
Back Pain: 7 people, 50.00%
Hepatitis C: 6 people, 42.86%
Chest Pain: 4 people, 28.57%
Nausea (feeling of having an urge to vomit): 3 people, 21.43%
High Blood Cholesterol: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Centrum and have Hyperreflexia?

- Check whether Hyperreflexia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Centrum:

Centrum (34,683 reports)

Hyperreflexia treatments and more:

Hyperreflexia (4,677 reports)

How severe was Hyperreflexia and when was it recovered:

Hyperreflexia in Centrum

Expand to all the drugs that have ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e:

Hyperreflexia and drugs with ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (55 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Centrum:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperreflexia:

Hyperreflexia (474 drugs)

Browse all the conditions that are associated with Hyperreflexia:

Hyperreflexia (644 conditions)

Drugs similar to Centrum and Hyperreflexia :

Vitamin d side effect: Hyperreflexia

How the study uses the data?

The study uses data from the FDA. It is based on ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (the active ingredients of Centrum) and Centrum (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.