Climara pro and Vaginal bleeding between periods - a phase IV clinical study of FDA data

Summary:

Vaginal bleeding between periods is reported as a side effect among people who take Climara pro (estradiol; levonorgestrel), especially for people who are 50-59 old, have been taking the drug for < 1 month also take Climara, and have Hot flush.

The phase IV clinical study analyzes which people have Vaginal bleeding between periods when taking Climara pro. It is created by eHealthMe based on reports of 1,372 people who have side effects when taking Climara pro from the FDA, and is updated regularly.

What is Climara pro?

Climara pro has active ingredients of estradiol; levonorgestrel. It is often used in menopausal symptoms. eHealthMe is studying from 1,396 Climara pro users. Check the latest studies of Climara pro.

What is Vaginal bleeding between periods?

Vaginal bleeding between periods is found to be associated with 577 drugs and 1,467 conditions by eHealthMe. Check the latest studies of Vaginal bleeding between periods.

On Jul, 17, 2026

1,372 people reported to have side effects when taking Climara pro.
Among them, 25 people (1.82%) have Vaginal bleeding between periods.

Could Climara pro cause Vaginal bleeding between periods?

Among these 25 people:

How long have people been on Climara pro when they have Vaginal bleeding between periods? *

What is the age of people who have Vaginal bleeding between periods when taking Climara pro? *

What are other drugs people take besides Climara pro? *

Synthroid: 1 person, 4.00%
Estradiol: 1 person, 4.00%
Climara: 1 person, 4.00%

What are other side effects people have besides Vaginal bleeding between periods? *

Drug Ineffective: 3 people, 12.00%
Rashes (redness): 2 people, 8.00%
Vaginal Bleeding: 1 person, 4.00%
Hot Flush (sudden feelings of heat): 1 person, 4.00%
Application Site Discoloration: 1 person, 4.00%
Application Site Irritation: 1 person, 4.00%
Application Site Rash: 1 person, 4.00%
Drug Effect Decreased: 1 person, 4.00%
Hair Growth Abnormal: 1 person, 4.00%
Hair Loss: 1 person, 4.00%

What are the existing conditions these people have? *

Hot Flush (sudden feelings of heat): 4 people, 16.00%
Hormone Level Abnormal: 2 people, 8.00%
Postmenopause: 1 person, 4.00%
Menopause (end of monthly cycles in women): 1 person, 4.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 4.00%

* Approximation only. Some reports may have incomplete information.

Do you take Climara pro and have Vaginal bleeding between periods?

- Check whether Vaginal bleeding between periods is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Climara pro:

Climara pro (1,396 reports)

Browse all side effects of Climara pro:

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Browse all the drugs that are associated with Vaginal bleeding between periods:

Vaginal bleeding between periods (577 drugs)

Browse all the conditions that are associated with Vaginal bleeding between periods:

Vaginal bleeding between periods (1,467 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol; levonorgestrel (the active ingredients of Climara pro) and Climara pro (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.