Climara and Swallowing difficulty - a phase IV clinical study of FDA data

Summary:

Swallowing difficulty is reported as a side effect among people who take Climara (estradiol), especially for people who are female, 50-59 old, have been taking the drug for 6 - 12 months also take Premarin, and have High blood pressure.

The phase IV clinical study analyzes which people have Swallowing difficulty when taking Climara. It is created by eHealthMe based on reports of 6,607 people who have side effects when taking Climara from the FDA, and is updated regularly.

What is Climara?

Climara has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 6,706 Climara users. Check the latest studies of Climara.

What is Swallowing difficulty?

Swallowing difficulty is found to be associated with 2,402 drugs and 3,353 conditions by eHealthMe. Check the latest studies of Swallowing difficulty.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

6,607 people reported to have side effects when taking Climara.
Among them, 41 people (0.62%) have Swallowing difficulty.

Could Climara cause Swallowing difficulty?

Among these 41 people:

How long have people been on Climara when they have Swallowing difficulty? *

What is the gender of people who have Swallowing difficulty when taking Climara? *

female: 100 %
male: 0.0 %

What is the age of people who have Swallowing difficulty when taking Climara? *

What are other drugs people take besides Climara? *

What are other side effects people have besides Swallowing difficulty? *

Weight Decreased: 14 people, 34.15%
Gastritis (inflammation of stomach): 13 people, 31.71%
Asthma: 13 people, 31.71%
Fatigue (feeling of tiredness): 13 people, 31.71%
Stress And Anxiety: 13 people, 31.71%
High Blood Pressure: 12 people, 29.27%
Abdominal Pain: 12 people, 29.27%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 29.27%
Constipation: 12 people, 29.27%
Abdominal Pain Upper: 11 people, 26.83%

What are the existing conditions these people have? *

High Blood Pressure: 7 people, 17.07%
Cough: 6 people, 14.63%
Upper-Airway Cough Syndrome: 5 people, 12.20%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 9.76%
Migraine (headache): 4 people, 9.76%
Osteoporosis (bones weak and more likely to break): 3 people, 7.32%
Menopausal Depression (depression due to hormonal changes after stop of menses): 3 people, 7.32%
Barrett's Oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach): 3 people, 7.32%
Increased Upper Airway Secretion: 3 people, 7.32%
Hot Flush (sudden feelings of heat): 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

Do you take Climara and have Swallowing difficulty?

- Check whether Swallowing difficulty is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Climara:

Climara (6,706 reports)

Browse all side effects of Climara:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Swallowing difficulty:

Swallowing difficulty (2,402 drugs)

Browse all the conditions that are associated with Swallowing difficulty:

Swallowing difficulty (3,353 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Climara) and Climara (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.