Clonazepam and Terminal insomnia - a phase IV clinical study of FDA data

Summary:

Terminal insomnia is reported as a side effect among people who take Clonazepam (clonazepam), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Xyrem, and have Frontal lobe epilepsy.

The phase IV clinical study analyzes which people have Terminal insomnia when taking Clonazepam. It is created by eHealthMe based on reports of 140,365 people who have side effects when taking Clonazepam from the FDA, and is updated regularly.

What is Clonazepam?

Clonazepam has active ingredients of clonazepam. It is often used in stress and anxiety. eHealthMe is studying from 146,271 Clonazepam users. Check the latest studies of Clonazepam.

What is Terminal insomnia?

Terminal insomnia (a sleep disorder in which there is an inability to fall asleep or to stay asleep as long as desired) is found to be associated with 206 drugs and 345 conditions by eHealthMe. Check the latest studies of Terminal insomnia.

On Aug, 11, 2026

140,365 people reported to have side effects when taking Clonazepam.
Among them, 39 people (0.03%) have Terminal insomnia.

Could Clonazepam cause Terminal insomnia?

Among these 39 people:

How long have people been on Clonazepam when they have Terminal insomnia? *

What is the gender of people who have Terminal insomnia when taking Clonazepam? *

female: 54.05 %
male: 45.95 %

What is the age of people who have Terminal insomnia when taking Clonazepam? *

What are other drugs people take besides Clonazepam? *

What are other side effects people have besides Terminal insomnia? *

Insomnia (sleeplessness): 16 people, 41.03%
Fatigue (feeling of tiredness): 16 people, 41.03%
Nervousness: 15 people, 38.46%
Depressed Mood: 15 people, 38.46%
Poor Quality Sleep: 14 people, 35.90%
Middle Insomnia (difficulty returning to sleep after awakening either in the middle of the night): 12 people, 30.77%
Sleep Apnea Syndrome: 11 people, 28.21%
Upper Airway Obstruction: 10 people, 25.64%
Obstructive Airways Disorder (a progressive disease that makes it hard to breathe): 9 people, 23.08%
Agitation (state of anxiety or nervous excitement): 8 people, 20.51%

What are the existing conditions these people have? *

Frontal Lobe Epilepsy (recurring seizures that arise in the frontal lobes of the brain): 9 people, 23.08%
Depression: 7 people, 17.95%
Psychotic Disorder: 4 people, 10.26%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 3 people, 7.69%
Insomnia (sleeplessness): 3 people, 7.69%
Sleep Disorder: 3 people, 7.69%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 7.69%
Salivary Hypersecretion (excess saliva secretion): 3 people, 7.69%
Obsessive Thoughts (intrusive thoughts that produce uneasiness, apprehension, fear, or worry): 3 people, 7.69%
Temporal Lobe Epilepsy (a term that refers to a condition where seizures are generated in the portion of the brain called the temporal lobe): 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

Do you take Clonazepam and have Terminal insomnia?

- Check whether Terminal insomnia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Clonazepam:

Clonazepam (146,271 reports)

Browse all side effects of Clonazepam:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Terminal insomnia:

Terminal insomnia (206 drugs)

Browse all the conditions that are associated with Terminal insomnia:

Terminal insomnia (345 conditions)

Related publications that referenced our studies

McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .
McFarlane SI, "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2015 Jan .
Ashkar AG, Goldberg T, Maraj I, Masters A, McFarlane SI, "Torsades De Pointes Induced by Methadone and Clonazepam Use", International Journal of Medical and Pharmaceutical Case Reports, 2015 Jan .
McFarlane, S. I. , "Torsades de Pointes induced by Methadone and Clonazepam Use", , 2014 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on clonazepam (the active ingredients of Clonazepam) and Clonazepam (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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