Clonidine and Aseptic necrosis - a phase IV clinical study of FDA data

Summary:

Aseptic necrosis is reported as a side effect among people who take Clonidine (clonidine), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Aredia, and have Metastases to bone.

The phase IV clinical study analyzes which people have Aseptic necrosis when taking Clonidine. It is created by eHealthMe based on reports of 63,883 people who have side effects when taking Clonidine from the FDA, and is updated regularly.

What is Clonidine?

Clonidine has active ingredients of clonidine. It is often used in high blood pressure. eHealthMe is studying from 65,645 Clonidine users. Check the latest studies of Clonidine.

What is Aseptic necrosis?

Aseptic necrosis (the death of bone tissue due to a lack of blood supply) is found to be associated with 1,344 drugs and 1,696 conditions by eHealthMe. Check the latest studies of Aseptic necrosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

63,883 people reported to have side effects when taking Clonidine.
Among them, 98 people (0.15%) have Aseptic necrosis.

Among these 98 people:

How long have people been on Clonidine when they have Aseptic necrosis? *

What is the gender of people who have Aseptic necrosis when taking Clonidine? *

female: 83.51 %
male: 16.49 %

What is the age of people who have Aseptic necrosis when taking Clonidine? *

What are other drugs people take besides Clonidine? *

What are other side effects people have besides Aseptic necrosis? *

Pain: 57 people, 58.16%
Stress And Anxiety: 51 people, 52.04%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 46 people, 46.94%
Bone Disorder: 39 people, 39.80%
Gait Disturbance: 34 people, 34.69%
Weakness: 33 people, 33.67%
Back Pain: 32 people, 32.65%
Anhedonia (inability to experience pleasure from activities usually found enjoyable): 32 people, 32.65%
Tooth Abscess (pus formation in tooth): 32 people, 32.65%
Urinary Tract Infection: 31 people, 31.63%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 21 people, 21.43%
Muscle Spasms (muscle contraction): 16 people, 16.33%
Breast Cancer: 16 people, 16.33%
Breast Cancer Metastatic: 16 people, 16.33%
Constipation: 15 people, 15.31%
Multiple Myeloma (cancer of the plasma cells): 14 people, 14.29%
Hiv Infection: 13 people, 13.27%
Pain: 10 people, 10.20%
Neoplasm Malignant (cancer tumour): 9 people, 9.18%
Osteoporosis (bones weak and more likely to break): 7 people, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Clonidine and have Aseptic necrosis?

- Check whether Aseptic necrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Clonidine:

Clonidine (65,645 reports)

Aseptic necrosis treatments and more:

Aseptic necrosis (59,829 reports)

Browse all side effects of Clonidine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aseptic necrosis:

Aseptic necrosis (1,344 drugs)

Browse all the conditions that are associated with Aseptic necrosis:

Aseptic necrosis (1,696 conditions)

Related publications that referenced our studies

Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .
Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on clonidine (the active ingredients of Clonidine) and Clonidine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.