Clonidine and Brain death - a phase IV clinical study of FDA data

Summary:

Brain death is reported as a side effect among people who take Clonidine (clonidine), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lisinopril, and have Chronic kidney disease.

The study is created by eHealthMe based on reports of 63,883 people who have side effects when taking Clonidine from the FDA, and is updated regularly.

What is Clonidine?

Clonidine has active ingredients of clonidine. It is often used in high blood pressure. eHealthMe is studying from 65,644 Clonidine users. Check the latest studies of Clonidine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

63,883 people reported to have side effects when taking Clonidine.
Among them, 33 people (0.05%) died.

Among these 33 people:

How long have people been on Clonidine when they died? *

What is the gender of people who died when taking Clonidine? *

female: 58.06 %
male: 41.94 %

What is the age of people who died when taking Clonidine? *

What are other drugs people take besides Clonidine? *

What are other side effects people have before they died? *

Cardiac Arrest: 12 people, 36.36%
Consciousness - Decreased: 11 people, 33.33%
Headache (pain in head): 8 people, 24.24%
Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 6 people, 18.18%
Arrhythmias (irregular heartbeat): 6 people, 18.18%
Cardiogenic Shock (inadequate circulation of blood): 5 people, 15.15%
Unresponsive To Stimuli: 5 people, 15.15%
Compartment Syndrome (painful condition that occurs when pressure within the muscles builds to dangerous levels): 5 people, 15.15%
Haemorrhage (bleeding): 5 people, 15.15%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 5 people, 15.15%

What are the existing conditions these people have? *

Chronic Kidney Disease: 3 people, 9.09%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 2 people, 6.06%
Dementia (madness): 2 people, 6.06%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 3.03%
Diabetic Retinal Oedema (excessive build-up of fluid in the retina due to diabetes): 1 person, 3.03%
Anger: 1 person, 3.03%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 3.03%
Blood Pressure Abnormal: 1 person, 3.03%
Blood Pressure Orthostatic: 1 person, 3.03%
Cardiac Disorder: 1 person, 3.03%

* Approximation only. Some reports may have incomplete information.

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Clonidine:

Clonidine (65,644 reports)

Expand to all the drugs that have ingredients of clonidine:

Brain death and drugs with ingredients of clonidine (33 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Clonidine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Brain death:

Brain death (316 drugs)

Browse all the conditions that are associated with Brain death:

Brain death (489 conditions)

Related publications that referenced our studies

Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .
Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on clonidine (the active ingredients of Clonidine) and Clonidine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.