Clonidine and Gastrointestinal perforation - a phase IV clinical study of FDA data

Summary:

Gastrointestinal perforation is reported as a side effect among people who take Clonidine (clonidine), especially for people who are female, 40-49 old, have been taking the drug for 1 - 2 years also take Norvasc, and have Gastric disorder.

The phase IV clinical study analyzes which people have Gastrointestinal perforation when taking Clonidine. It is created by eHealthMe based on reports of 63,883 people who have side effects when taking Clonidine from the FDA, and is updated regularly.

What is Clonidine?

Clonidine has active ingredients of clonidine. It is often used in high blood pressure. eHealthMe is studying from 65,644 Clonidine users. Check the latest studies of Clonidine.

What is Gastrointestinal perforation?

Gastrointestinal perforation (hole in the digestive tract) is found to be associated with 929 drugs and 1,394 conditions by eHealthMe. Check the latest studies of Gastrointestinal perforation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

63,883 people reported to have side effects when taking Clonidine.
Among them, 33 people (0.05%) have Gastrointestinal perforation.

Could Clonidine cause Gastrointestinal perforation?

Among these 33 people:

How long have people been on Clonidine when they have Gastrointestinal perforation? *

What is the gender of people who have Gastrointestinal perforation when taking Clonidine? *

female: 63.64 %
male: 36.36 %

What is the age of people who have Gastrointestinal perforation when taking Clonidine? *

What are other drugs people take besides Clonidine? *

What are other side effects people have besides Gastrointestinal perforation? *

Sepsis (a severe blood infection that can lead to organ failure and death): 9 people, 27.27%
Nausea (feeling of having an urge to vomit): 6 people, 18.18%
Postoperative Wound Infection: 6 people, 18.18%
Abdominal Pain: 6 people, 18.18%
Pneumonia: 6 people, 18.18%
Dyspnea (difficult or laboured breathing): 5 people, 15.15%
Anaemia (lack of blood): 4 people, 12.12%
Post Procedural Fistula: 4 people, 12.12%
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs): 4 people, 12.12%
Indigestion: 4 people, 12.12%

What are the existing conditions these people have? *

Gastric Disorder (disease of stomach): 6 people, 18.18%
Migraine (headache): 5 people, 15.15%
Bladder Disorder: 5 people, 15.15%
Lung Cancer - Non-Small Cell (lung cancer): 4 people, 12.12%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 12.12%
Acute Kidney Failure: 3 people, 9.09%
Nausea (feeling of having an urge to vomit): 3 people, 9.09%
Idiopathic Thrombocytopenic Purpura (Itp) (bleeding disorder in which the immune system destroys platelets, which are necessary for normal blood clotting): 3 people, 9.09%
Diabetes: 2 people, 6.06%
High Blood Cholesterol: 2 people, 6.06%

* Approximation only. Some reports may have incomplete information.

Do you take Clonidine and have Gastrointestinal perforation?

- Check whether Gastrointestinal perforation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Clonidine:

Clonidine (65,644 reports)

Browse all side effects of Clonidine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gastrointestinal perforation:

Gastrointestinal perforation (929 drugs)

Browse all the conditions that are associated with Gastrointestinal perforation:

Gastrointestinal perforation (1,394 conditions)

Related publications that referenced our studies

Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .
Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on clonidine (the active ingredients of Clonidine) and Clonidine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.