Clonidine and Hypoxic-ischaemic encephalopathy - a phase IV clinical study of FDA data

Summary:

Hypoxic-ischaemic encephalopathy is reported as a side effect among people who take Clonidine (clonidine), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Sevoflurane, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Hypoxic-ischaemic encephalopathy when taking Clonidine. It is created by eHealthMe based on reports of 63,883 people who have side effects when taking Clonidine from the FDA, and is updated regularly.

What is Clonidine?

Clonidine has active ingredients of clonidine. It is often used in high blood pressure. eHealthMe is studying from 65,645 Clonidine users. Check the latest studies of Clonidine.

What is Hypoxic-ischaemic encephalopathy?

Hypoxic-ischaemic encephalopathy (a condition that occurs when the entire brain is deprived of an adequate oxygen supply, but the deprivation isn't total) is found to be associated with 366 drugs and 600 conditions by eHealthMe. Check the latest studies of Hypoxic-ischaemic encephalopathy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

63,883 people reported to have side effects when taking Clonidine.
Among them, 40 people (0.06%) have Hypoxic-ischaemic encephalopathy.

Could Clonidine cause Hypoxic-ischaemic encephalopathy?

Among these 40 people:

How long have people been on Clonidine when they have Hypoxic-ischaemic encephalopathy? *

What is the gender of people who have Hypoxic-ischaemic encephalopathy when taking Clonidine? *

female: 25.64 %
male: 74.36 %

What is the age of people who have Hypoxic-ischaemic encephalopathy when taking Clonidine? *

What are other drugs people take besides Clonidine? *

What are other side effects people have besides Hypoxic-ischaemic encephalopathy? *

Cardiac Arrest: 15 people, 37.50%
Ventricular Fibrillation (abnormally irregular heart rhythm): 13 people, 32.50%
Agitation (state of anxiety or nervous excitement): 12 people, 30.00%
Hypotension (abnormally low blood pressure): 10 people, 25.00%
Hypokalemia (low potassium): 10 people, 25.00%
Arrhythmias (irregular heartbeat): 10 people, 25.00%
Cardiac Failure Congestive: 8 people, 20.00%
Acute Kidney Failure: 7 people, 17.50%
Dyspnea (difficult or laboured breathing): 6 people, 15.00%
Nausea (feeling of having an urge to vomit): 6 people, 15.00%

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 15.00%
Pain: 5 people, 12.50%
Diabetes: 5 people, 12.50%
High Blood Cholesterol: 4 people, 10.00%
Cardiac Disorder: 3 people, 7.50%
Anger: 2 people, 5.00%
Blood Phosphorus Increased: 2 people, 5.00%
Gilles De La Tourette Syndrome (a condition that causes people to make repeated, quick movements or sounds that they cannot control): 2 people, 5.00%
Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 2 people, 5.00%
Anaemia (lack of blood): 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Clonidine and have Hypoxic-ischaemic encephalopathy?

- Check whether Hypoxic-ischaemic encephalopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Clonidine:

Clonidine (65,645 reports)

Browse all side effects of Clonidine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypoxic-ischaemic encephalopathy:

Hypoxic-ischaemic encephalopathy (366 drugs)

Browse all the conditions that are associated with Hypoxic-ischaemic encephalopathy:

Hypoxic-ischaemic encephalopathy (600 conditions)

Related publications that referenced our studies

Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .
Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on clonidine (the active ingredients of Clonidine) and Clonidine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.