Clonidine and Injection site irritation - a phase IV clinical study of FDA data

Summary:

Injection site irritation is reported as a side effect among people who take Clonidine (clonidine), especially for people who are female, 50-59 old, also take Humira, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Injection site irritation when taking Clonidine. It is created by eHealthMe based on reports of 63,883 people who have side effects when taking Clonidine from the FDA, and is updated regularly.

What is Clonidine?

Clonidine has active ingredients of clonidine. It is often used in high blood pressure. eHealthMe is studying from 65,638 Clonidine users. Check the latest studies of Clonidine.

What is Injection site irritation?

Injection site irritation is found to be associated with 458 drugs and 509 conditions by eHealthMe. Check the latest studies of Injection site irritation.

On Apr, 10, 2026

63,883 people reported to have side effects when taking Clonidine.
Among them, 23 people (0.04%) have Injection site irritation.

Could Clonidine cause Injection site irritation?

Among these 23 people:

What is the gender of people who have Injection site irritation when taking Clonidine? *

female: 82.61 %
male: 17.39 %

What is the age of people who have Injection site irritation when taking Clonidine? *

What are other drugs people take besides Clonidine? *

What are other side effects people have besides Injection site irritation? *

Injection Site Erythema (redness at injection site): 8 people, 34.78%
Injection Site Pain: 4 people, 17.39%
Injection Site Pruritus (severe itching at injection site): 4 people, 17.39%
Abdominal Discomfort: 3 people, 13.04%
Injection Site Haemorrhage (bleeding from injection site): 3 people, 13.04%
Cellulitis (infection under the skin): 2 people, 8.70%
White Blood Cell Count Increased: 2 people, 8.70%
Headache (pain in head): 2 people, 8.70%
Injection Site Urticaria (rash of round, red welts on the skin at injection site): 2 people, 8.70%
Intervertebral Disc Degeneration (spinal disc degeneration): 2 people, 8.70%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 12 people, 52.17%
Psoriasis (immune-mediated disease that affects the skin): 3 people, 13.04%
Pain: 3 people, 13.04%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 13.04%
Depression: 3 people, 13.04%
Gastric Ulcer (stomach ulcer): 2 people, 8.70%
Osteoporosis (bones weak and more likely to break): 2 people, 8.70%
Renal Disorder (kidney disease): 2 people, 8.70%
Joint Pain: 2 people, 8.70%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

Do you take Clonidine and have Injection site irritation?

- Check whether Injection site irritation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Clonidine:

Clonidine (65,638 reports)

Browse all side effects of Clonidine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Injection site irritation:

Injection site irritation (458 drugs)

Browse all the conditions that are associated with Injection site irritation:

Injection site irritation (509 conditions)

Related publications that referenced our studies

Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .
Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on clonidine (the active ingredients of Clonidine) and Clonidine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.