Clonidine and Spondylolisthesis - a phase IV clinical study of FDA data

Summary:

Spondylolisthesis is reported as a side effect among people who take Clonidine (clonidine), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Aredia, and have Pain.

The phase IV clinical study analyzes which people have Spondylolisthesis when taking Clonidine. It is created by eHealthMe based on reports of 63,883 people who have side effects when taking Clonidine from the FDA, and is updated regularly.

What is Clonidine?

Clonidine has active ingredients of clonidine. It is often used in high blood pressure. eHealthMe is studying from 65,645 Clonidine users. Check the latest studies of Clonidine.

What is Spondylolisthesis?

Spondylolisthesis (displacement of a vertebra or the vertebral column in relation to the vertebrae below) is found to be associated with 567 drugs and 493 conditions by eHealthMe. Check the latest studies of Spondylolisthesis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

63,883 people reported to have side effects when taking Clonidine.
Among them, 74 people (0.12%) have Spondylolisthesis.

Could Clonidine cause Spondylolisthesis?

Among these 74 people:

How long have people been on Clonidine when they have Spondylolisthesis? *

What is the gender of people who have Spondylolisthesis when taking Clonidine? *

female: 85.92 %
male: 14.08 %

What is the age of people who have Spondylolisthesis when taking Clonidine? *

What are other drugs people take besides Clonidine? *

What are other side effects people have besides Spondylolisthesis? *

Pain: 48 people, 64.86%
Depression: 46 people, 62.16%
Stress And Anxiety: 46 people, 62.16%
Back Pain: 45 people, 60.81%
Spinal Osteoarthritis (joint cartilage loss in spine): 45 people, 60.81%
Dyspnea (difficult or laboured breathing): 43 people, 58.11%
Joint Pain: 43 people, 58.11%
Intervertebral Disc Protrusion (spinal disc protrusion): 42 people, 56.76%
Scoliosis (a medical condition in which a person's spine is curved from side to side): 40 people, 54.05%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 39 people, 52.70%

What are the existing conditions these people have? *

Pain: 22 people, 29.73%
Multiple Myeloma (cancer of the plasma cells): 19 people, 25.68%
Bone Loss: 13 people, 17.57%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 12 people, 16.22%
Hypomania (a mild form of mania, marked by elation and hyperactivity): 11 people, 14.86%
Oedema (fluid collection in tissue): 11 people, 14.86%
Osteoporosis (bones weak and more likely to break): 9 people, 12.16%
Fluid Retention (an abnormal accumulation of fluid in the blood): 7 people, 9.46%
Protein S Deficiency: 4 people, 5.41%
Diabetes: 3 people, 4.05%

* Approximation only. Some reports may have incomplete information.

Do you take Clonidine and have Spondylolisthesis?

- Check whether Spondylolisthesis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Clonidine:

Clonidine (65,645 reports)

Browse all side effects of Clonidine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Spondylolisthesis:

Spondylolisthesis (567 drugs)

Browse all the conditions that are associated with Spondylolisthesis:

Spondylolisthesis (493 conditions)

Related publications that referenced our studies

Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .
Teimoory M, Arefi M, Behnoush B, Bastani B, "Promethazine and Treatment Refractory Agitation in Clonidine Toxicity", International Journal of Medical Toxicology and Forensic Medicine, 2013 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on clonidine (the active ingredients of Clonidine) and Clonidine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.