Clozapine and Pain disorder - a phase IV clinical study of FDA data

Summary:

Pain disorder is reported as a side effect among people who take Clozapine (clozapine), especially for people who are male, 60+ old, have been taking the drug for 5 - 10 years also take Amisulpride, and have Agitation.

The phase IV clinical study analyzes which people have Pain disorder when taking Clozapine. It is created by eHealthMe based on reports of 83,401 people who have side effects when taking Clozapine from the FDA, and is updated regularly.

What is Clozapine?

Clozapine has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 83,728 Clozapine users. Check the latest studies of Clozapine.

What is Pain disorder?

Pain disorder is found to be associated with 107 drugs and 270 conditions by eHealthMe. Check the latest studies of Pain disorder.

On May, 12, 2026

83,401 people reported to have side effects when taking Clozapine.
Among them, 9 people (0.01%) have Pain disorder.

Among these 9 people:

How long have people been on Clozapine when they have Pain disorder? *

What is the gender of people who have Pain disorder when taking Clozapine? *

female: 44.44 %
male: 55.56 %

What is the age of people who have Pain disorder when taking Clozapine? *

What are other drugs people take besides Clozapine? *

What are other side effects people have besides Pain disorder? *

Depression: 5 people, 55.56%
Dyskinesia (abnormality or impairment of voluntary movement): 4 people, 44.44%
Faeces Hard: 3 people, 33.33%
Hyperkinesia (higher than normal levels of potassium in the circulating blood; associated with kidney failure or sometimes with the use of diuretic drugs): 3 people, 33.33%
Thinking Abnormal: 3 people, 33.33%
Headache (pain in head): 3 people, 33.33%
Hallucinations (sensations that appear real but are created by your mind): 3 people, 33.33%
Hallucination, Visual (seeing things that aren't there): 3 people, 33.33%
Gait Disturbance: 3 people, 33.33%
Freezing Phenomenon: 3 people, 33.33%

What are the existing conditions these people have? *

Pain: 3 people, 33.33%
Bowel Movement Irregularity: 3 people, 33.33%
Agitation (state of anxiety or nervous excitement): 3 people, 33.33%
Parkinson's Disease: 2 people, 22.22%
Musculoskeletal Stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves): 2 people, 22.22%
Freezing Phenomenon: 2 people, 22.22%

* Approximation only. Some reports may have incomplete information.

Do you take Clozapine and have Pain disorder?

- Check whether Pain disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Clozapine:

Clozapine (83,728 reports)

Pain disorder treatments and more:

Pain disorder (617 reports)

Browse all side effects of Clozapine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pain disorder:

Pain disorder (107 drugs)

Browse all the conditions that are associated with Pain disorder:

Pain disorder (270 conditions)

Related publications that referenced our studies

Grover S, Sahoo S, "Clozapine induced akathisia: A case report and review of the evidence", Indian journal of pharmacology, 2015 Jan .
Yaylaci S, Yilmaz EU, Guclu E, Kumsar NA, Tamer A, Karabay O, "Clozapine-Induced Febrile Neutropenia and Cellulitis", Turkish journal of emergency medicine, 2014 Mar .
Grover S, Sahoo S, "Clozapine induced akathisia: A case report and review of the evidence", Indian journal of pharmacology, 2015 Jan .
Yaylaci S, Yilmaz EU, Guclu E, Kumsar NA, Tamer A, Karabay O, "Clozapine-Induced Febrile Neutropenia and Cellulitis", Turkish journal of emergency medicine, 2014 Mar .

How the study uses the data?

The study uses data from the FDA. It is based on clozapine (the active ingredients of Clozapine) and Clozapine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.