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Clozaril and Sinus rhythm - a phase IV clinical study of FDA data

Summary:

Sinus rhythm is reported as a side effect among people who take Clozaril (clozapine), especially for people who are female, 60+ old, also take Apixaban, and have High blood pressure.

The phase IV clinical study analyzes which people have Sinus rhythm when taking Clozaril. It is created by eHealthMe based on reports of 64,938 people who have side effects when taking Clozaril from the FDA, and is updated regularly.

What is Clozaril?

Clozaril has active ingredients of clozapine. It is often used in schizophrenia. eHealthMe is studying from 65,127 Clozaril users. Check the latest studies of Clozaril.

What is Sinus rhythm?

Sinus rhythm (normal beating of the heart) is found to be associated with 121 drugs and 119 conditions by eHealthMe. Check the latest studies of Sinus rhythm.

On Jul, 28, 2026

64,938 people reported to have side effects when taking Clozaril.
Among them, 21 people (0.03%) have Sinus rhythm.

Could Clozaril cause Sinus rhythm?

Among these 21 people:

What is the gender of people who have Sinus rhythm when taking Clozaril? *

  • female: 52.63 %
  • male: 47.37 %

What is the age of people who have Sinus rhythm when taking Clozaril? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 10 %
  • 20-29: 10 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 40 %
  • 60+: 40 %

What are other drugs people take besides Clozaril? *

  1. Pantoprazole: 9 people, 42.86%
  2. Olanzapine: 9 people, 42.86%
  3. Apixaban: 9 people, 42.86%
  4. Vitamins: 3 people, 14.29%
  5. Venlafaxine Hydrochloride: 3 people, 14.29%
  6. Perindopril Erbumine: 1 person, 4.76%
  7. Invega Sustenna: 1 person, 4.76%

What are other side effects people have besides Sinus rhythm? *

  1. Atrioventricular Block First Degree (heart block first degree): 9 people, 42.86%
  2. C-Reactive Protein Abnormal: 9 people, 42.86%
  3. Troponin T Increased: 5 people, 23.81%
  4. Electrocardiogram St-T Change: 5 people, 23.81%
  5. Atrioventricular Block Complete (heart block complete): 4 people, 19.05%
  6. Sinus Tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 3 people, 14.29%
  7. Delirium (wild excitement): 2 people, 9.52%
  8. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 9.52%
  9. Electrocardiogram Abnormal: 2 people, 9.52%
  10. Blood Creatine Phosphokinase Increased: 2 people, 9.52%

What are the existing conditions these people have? *

  1. Schizophrenia, Paranoid Type (delusions and auditory hallucinations but relatively normal intellectual functioning and expression of affect): 1 person, 4.76%
  2. High Blood Pressure: 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Clozaril and have Sinus rhythm?

- Check whether Sinus rhythm is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Clozaril:

Sinus rhythm treatments and more:

How severe was Sinus rhythm and when was it recovered:

Expand to all the drugs that have ingredients of clozapine:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Clozaril:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus rhythm:

Browse all the conditions that are associated with Sinus rhythm:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on clozapine (the active ingredients of Clozaril) and Clozaril (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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