Co-codamol and Irritable bowel syndrome - a phase IV clinical study of FDA data

Summary:

Irritable bowel syndrome is reported as a side effect among people who take Co-codamol (acetaminophen; codeine phosphate), especially for people who are female, 30-39 old, also take Simponi, and have Ankylosing spondylitis.

The phase IV clinical study analyzes which people have Irritable bowel syndrome when taking Co-codamol. It is created by eHealthMe based on reports of 1,873 people who have side effects when taking Co-codamol from the FDA, and is updated regularly.

What is Co-codamol?

Co-codamol has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 2,364 Co-codamol users. Check the latest studies of Co-codamol.

What is Irritable bowel syndrome?

Irritable bowel syndrome is found to be associated with 1,317 drugs and 2,121 conditions by eHealthMe. Check the latest studies of Irritable bowel syndrome.

On Jul, 13, 2026

1,873 people reported to have side effects when taking Co-codamol.
Among them, 12 people (0.64%) have Irritable bowel syndrome.

Could Co-codamol cause Irritable bowel syndrome?

Among these 12 people:

What is the gender of people who have Irritable bowel syndrome when taking Co-codamol? *

female: 90.91 %
male: 9.09 %

What is the age of people who have Irritable bowel syndrome when taking Co-codamol? *

What are other drugs people take besides Co-codamol? *

What are other side effects people have besides Irritable bowel syndrome? *

Diarrhea: 11 people, 91.67%
White Blood Cell Count Increased: 8 people, 66.67%
Neutrophil Count Abnormal (abnormal number of neutrophil a type of blood cell): 8 people, 66.67%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 8 people, 66.67%
Haematochezia (passage of stools containing blood): 8 people, 66.67%
Loss Of Consciousness: 8 people, 66.67%
Nausea And Vomiting: 8 people, 66.67%
Abdominal Pain: 8 people, 66.67%
Serum Ferritin Abnormal: 8 people, 66.67%
Abnormal Faeces (abnormal stool): 2 people, 16.67%

What are the existing conditions these people have? *

Ankylosing Spondylitis (type of arthritis affecting the spine): 8 people, 66.67%
Depression: 2 people, 16.67%
Stress And Anxiety: 1 person, 8.33%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 1 person, 8.33%
Blood Pressure Abnormal: 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Co-codamol and have Irritable bowel syndrome?

- Check whether Irritable bowel syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Co-codamol:

Co-codamol (2,364 reports)

Irritable bowel syndrome treatments and more:

Irritable bowel syndrome (49,237 reports)

How severe was Irritable bowel syndrome and when was it recovered:

Irritable bowel syndrome in Co-codamol

Expand to all the drugs that have ingredients of acetaminophen; codeine phosphate:

Irritable bowel syndrome and drugs with ingredients of acetaminophen; codeine phosphate (1,482 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Co-codamol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Irritable bowel syndrome:

Irritable bowel syndrome (1,317 drugs)

Browse all the conditions that are associated with Irritable bowel syndrome:

Irritable bowel syndrome (2,121 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; codeine phosphate (the active ingredients of Co-codamol) and Co-codamol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.