Codeine sulfate and Muscle rigidity - a phase IV clinical study of FDA data

Summary:

Muscle rigidity is reported as a side effect among people who take Codeine sulfate (codeine sulfate), especially for people who are female, 30-39 old, have been taking the drug for 1 - 6 months also take Lorazepam, and have Psychotic disorder.

The phase IV clinical study analyzes which people have Muscle rigidity when taking Codeine sulfate. It is created by eHealthMe based on reports of 4,237 people who have side effects when taking Codeine sulfate from the FDA, and is updated regularly.

What is Codeine sulfate?

Codeine sulfate has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 4,510 Codeine sulfate users. Check the latest studies of Codeine sulfate.

What is Muscle rigidity?

Muscle rigidity (muscle stiffness) is found to be associated with 785 drugs and 1,035 conditions by eHealthMe. Check the latest studies of Muscle rigidity.

On Jul, 16, 2026

4,237 people reported to have side effects when taking Codeine sulfate.
Among them, 14 people (0.33%) have Muscle rigidity.

Could Codeine sulfate cause Muscle rigidity?

Among these 14 people:

How long have people been on Codeine sulfate when they have Muscle rigidity? *

What is the gender of people who have Muscle rigidity when taking Codeine sulfate? *

female: 76.92 %
male: 23.08 %

What is the age of people who have Muscle rigidity when taking Codeine sulfate? *

What are other drugs people take besides Codeine sulfate? *

Lorazepam: 13 people, 92.86%
Omeprazole: 10 people, 71.43%
Mirtazapine: 10 people, 71.43%
Diazepam: 10 people, 71.43%
Clonazepam: 10 people, 71.43%
Zopiclone: 3 people, 21.43%
Olanzapine: 3 people, 21.43%
Acetaminophen: 3 people, 21.43%
Quetiapine Fumarate: 2 people, 14.29%
Paroxetine Hydrochloride: 1 person, 7.14%

What are other side effects people have besides Muscle rigidity? *

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 12 people, 85.71%
Weakness: 11 people, 78.57%
H1n1 Influenza (flu (influenza), which is caused by virus influenza a (h1n1)): 10 people, 71.43%
Muscle Spasms (muscle contraction): 10 people, 71.43%
Mood Swings (an extreme or rapid change in mood): 10 people, 71.43%
Malaise (a feeling of general discomfort or uneasiness): 10 people, 71.43%
Joint Pain: 10 people, 71.43%
Visual Impairment: 10 people, 71.43%
Hyperhidrosis (abnormally increased sweating): 10 people, 71.43%
Headache (pain in head): 10 people, 71.43%

What are the existing conditions these people have? *

Psychotic Disorder: 12 people, 85.71%
Sedation: 9 people, 64.29%
Extrapyramidal Disorder (involuntary muscle spasms in the face and neck): 9 people, 64.29%
Depression: 9 people, 64.29%
Post-Traumatic Stress Disorder: 7 people, 50.00%
Neck Pain: 5 people, 35.71%
Insomnia (sleeplessness): 3 people, 21.43%
Agitation (state of anxiety or nervous excitement): 3 people, 21.43%
Abdominal Pain: 3 people, 21.43%
Muscle Spasms (muscle contraction): 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine sulfate and have Muscle rigidity?

- Check whether Muscle rigidity is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine sulfate:

Codeine sulfate (4,510 reports)

Muscle rigidity treatments and more:

Muscle rigidity (16,888 reports)

Browse all side effects of Codeine sulfate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle rigidity:

Muscle rigidity (785 drugs)

Browse all the conditions that are associated with Muscle rigidity:

Muscle rigidity (1,035 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine sulfate) and Codeine sulfate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.