Codeine and Affect lability - a phase IV clinical study of FDA data

Summary:

Affect lability is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are female, 30-39 old, have been taking the drug for < 1 month also take Melatonin, and have Depression.

The phase IV clinical study analyzes which people have Affect lability when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,341 Codeine users. Check the latest studies of Codeine.

What is Affect lability?

Affect lability (emotional incontinence) is found to be associated with 784 drugs and 810 conditions by eHealthMe. Check the latest studies of Affect lability.

On Dec, 28, 2025

41,713 people reported to have side effects when taking Codeine.
Among them, 20 people (0.05%) have Affect lability.

Among these 20 people:

How long have people been on Codeine when they have Affect lability? *

What is the gender of people who have Affect lability when taking Codeine? *

female: 68.42 %
male: 31.58 %

What is the age of people who have Affect lability when taking Codeine? *

What are other drugs people take besides Codeine? *

What are other side effects people have besides Affect lability? *

Depression: 9 people, 45.00%
Drug Dependence: 8 people, 40.00%
Irritability: 6 people, 30.00%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 6 people, 30.00%
Mood Swings (an extreme or rapid change in mood): 5 people, 25.00%
Tremor (trembling or shaking movements in one or more parts of your body): 5 people, 25.00%
Fatigue (feeling of tiredness): 5 people, 25.00%
Disturbance In Attention: 5 people, 25.00%
Sleep Disorder: 5 people, 25.00%
Confusional State: 5 people, 25.00%

What are the existing conditions these people have? *

Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 4 people, 20.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 20.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 20.00%
Depression: 4 people, 20.00%
Stress And Anxiety: 3 people, 15.00%
Insomnia (sleeplessness): 2 people, 10.00%
Sleep Disorder: 2 people, 10.00%
Blood Pressure Abnormal: 1 person, 5.00%
Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 1 person, 5.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Affect lability?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,341 reports)

Affect lability treatments and more:

Affect lability (13,491 reports)

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Affect lability:

Affect lability (784 drugs)

Browse all the conditions that are associated with Affect lability:

Affect lability (810 conditions)

Drugs similar to Codeine and Affect lability :

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.