Norco and Affect lability - a phase IV clinical study of FDA data

Summary:

Affect lability is reported as a side effect among people who take Norco (acetaminophen; hydrocodone bitartrate), especially for people who are female, 40-49 old, also take Cymbalta, and have Depression.

The phase IV clinical study analyzes which people have Affect lability when taking Norco. It is created by eHealthMe based on reports of 71,619 people who have side effects when taking Norco from the FDA, and is updated regularly.

What is Norco?

Norco has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 74,060 Norco users. Check the latest studies of Norco.

What is Affect lability?

Affect lability (emotional incontinence) is found to be associated with 772 drugs and 813 conditions by eHealthMe. Check the latest studies of Affect lability.

On Jan, 16, 2026

71,619 people reported to have side effects when taking Norco.
Among them, 51 people (0.07%) have Affect lability.

Among these 51 people:

* Approximation only. Some reports may have incomplete information.

Do you take Norco and have Affect lability?

- Check whether Affect lability is associated with a drug or a condition (FREE)
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Norco:

Norco (74,060 reports)

Affect lability treatments and more:

Affect lability (13,491 reports)

How severe was Affect lability and when was it recovered:

Affect lability in Norco

Expand to all the drugs that have ingredients of acetaminophen; hydrocodone bitartrate:

Affect lability and drugs with ingredients of acetaminophen; hydrocodone bitartrate (244 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Norco side effects:

Norco side effect: Death (11,511 reports)
Norco side effect: Drug dependence (5,161 reports)

Browse all side effects of Norco:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Affect lability:

Browse all the drugs that are associated with Affect lability:

Affect lability (772 drugs)

Common conditions associated with Affect lability:

Depression: 1,410 reports
Pain: 839 reports
Alternative medicine - pain relief: 824 reports
Hypertension: 577 reports
High blood pressure: 576 reports
Tension: 476 reports
Ms: 451 reports
Childhood hyperkinesis: 379 reports
Contraception: 359 reports
Birth control: 251 reports

Browse all the conditions that are associated with Affect lability:

Affect lability (813 conditions)

Drugs similar to Norco and Affect lability :

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate (the active ingredients of Norco) and Norco (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.