Codeine and Initial insomnia - a phase IV clinical study of FDA data

Summary:

Initial insomnia is reported as a side effect among people who take Codeine (codeine sulfate), especially for people who are female, 60+ old, also take Magnesium, and have Ulcerative colitis.

The phase IV clinical study analyzes which people have Initial insomnia when taking Codeine. It is created by eHealthMe based on reports of 41,713 people who have side effects when taking Codeine from the FDA, and is updated regularly.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,341 Codeine users. Check the latest studies of Codeine.

What is Initial insomnia?

Initial insomnia (feeling of inadequate or poor-quality sleep) is found to be associated with 797 drugs and 677 conditions by eHealthMe. Check the latest studies of Initial insomnia.

On Dec, 06, 2025

41,713 people reported to have side effects when taking Codeine.
Among them, 15 people (0.04%) have Initial insomnia.

Among these 15 people:

What is the gender of people who have Initial insomnia when taking Codeine? *

female: 100 %
male: 0.0 %

What is the age of people who have Initial insomnia when taking Codeine? *

What are other drugs people take besides Codeine? *

What are other side effects people have besides Initial insomnia? *

Fatigue (feeling of tiredness): 14 people, 93.33%
Fall: 11 people, 73.33%
Poor Quality Sleep: 9 people, 60.00%
Diarrhea: 8 people, 53.33%
Joint Pain: 8 people, 53.33%
Nausea (feeling of having an urge to vomit): 7 people, 46.67%
Stress And Anxiety: 7 people, 46.67%
Drug Ineffective: 7 people, 46.67%
Weakness: 7 people, 46.67%
Peripheral Swelling: 6 people, 40.00%

What are the existing conditions these people have? *

Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 6 people, 40.00%
Parkinson's Disease: 5 people, 33.33%
Muscle Strain (an injury to a muscle in which the muscle fibres tear): 5 people, 33.33%
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 4 people, 26.67%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 4 people, 26.67%
Abnormal Faeces (abnormal stool): 4 people, 26.67%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 3 people, 20.00%
Wheezing (a high-pitched whistling sound made while you breath): 1 person, 6.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 6.67%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Codeine and have Initial insomnia?

- Check whether Initial insomnia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Codeine:

Codeine (42,341 reports)

Initial insomnia treatments and more:

Initial insomnia (12,139 reports)

Browse all side effects of Codeine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Initial insomnia:

Initial insomnia (797 drugs)

Browse all the conditions that are associated with Initial insomnia:

Initial insomnia (677 conditions)

Drugs similar to Codeine and Initial insomnia :

How the study uses the data?

The study uses data from the FDA. It is based on codeine sulfate (the active ingredients of Codeine) and Codeine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.