Colchicine and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Colchicine (colchicine), especially for people who are female, 60+ old, also take Humira, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Colchicine. It is created by eHealthMe based on reports of 21,541 people who have side effects when taking Colchicine from the FDA, and is updated regularly.

What is Colchicine?

Colchicine has active ingredients of colchicine. It is often used in gout. eHealthMe is studying from 21,826 Colchicine users. Check the latest studies of Colchicine.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 953 drugs and 1,229 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

On Jul, 19, 2026

21,541 people reported to have side effects when taking Colchicine.
Among them, 21 people (0.1%) have Knee joint replacement.

Could Colchicine cause Knee joint replacement?

Among these 21 people:

What is the gender of people who have Knee joint replacement when taking Colchicine? *

female: 70 %
male: 30 %

What is the age of people who have Knee joint replacement when taking Colchicine? *

What are other drugs people take besides Colchicine? *

What are other side effects people have besides Knee joint replacement? *

Joint Pain: 8 people, 38.10%
Pain: 7 people, 33.33%
Fall: 7 people, 33.33%
Weight Increased: 6 people, 28.57%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 6 people, 28.57%
Staphylococcal Infection (an infection with staphylococcus bacteria): 6 people, 28.57%
High Blood Pressure: 6 people, 28.57%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 5 people, 23.81%
Herpes Virus Infection: 5 people, 23.81%
Herpes Zoster: 5 people, 23.81%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 9 people, 42.86%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 14.29%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 14.29%
Type 2 Diabetes: 2 people, 9.52%
Back Pain: 2 people, 9.52%
Blood Pressure Abnormal: 2 people, 9.52%
Cardiac Disorder: 2 people, 9.52%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 9.52%
High Blood Pressure: 1 person, 4.76%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Colchicine and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Colchicine:

Colchicine (21,826 reports)

Browse all side effects of Colchicine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (953 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,229 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on colchicine (the active ingredients of Colchicine) and Colchicine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.