Combipatch and Application site warmth - a phase IV clinical study of FDA data

Summary:

Application site warmth is reported as a side effect among people who take Combipatch (estradiol; norethindrone acetate), especially for people who are female, 50-59 old, have been taking the drug for 6 - 12 months also take Synthroid, and have Hot flush.

The phase IV clinical study analyzes which people have Application site warmth when taking Combipatch. It is created by eHealthMe based on reports of 3,544 people who have side effects when taking Combipatch from the FDA, and is updated regularly.

What is Combipatch?

Combipatch has active ingredients of estradiol; norethindrone acetate. It is often used in menopause. eHealthMe is studying from 3,599 Combipatch users. Check the latest studies of Combipatch.

What is Application site warmth?

Application site warmth is found to be associated with 106 drugs and 205 conditions by eHealthMe. Check the latest studies of Application site warmth.

On Aug, 09, 2026

3,544 people reported to have side effects when taking Combipatch.
Among them, 11 people (0.31%) have Application site warmth.

Could Combipatch cause Application site warmth?

Among these 11 people:

How long have people been on Combipatch when they have Application site warmth? *

What is the gender of people who have Application site warmth when taking Combipatch? *

female: 100 %
male: 0.0 %

What is the age of people who have Application site warmth when taking Combipatch? *

What are other drugs people take besides Combipatch? *

Synthroid: 3 people, 27.27%
Vitamins: 1 person, 9.09%

What are other side effects people have besides Application site warmth? *

Application Site Erythema (redness of the skin at application site): 9 people, 81.82%
Application Site Pruritus (application site severe itching of the skin): 6 people, 54.55%
Application Site Pain: 3 people, 27.27%
Application Site Discoloration: 3 people, 27.27%
Application Site Irritation: 2 people, 18.18%
Application Site Inflammation: 2 people, 18.18%
Application Site Erosion: 2 people, 18.18%
Application Site Urticaria: 1 person, 9.09%
Application Site Ulcer: 1 person, 9.09%
Application Site Rash: 1 person, 9.09%

What are the existing conditions these people have? *

Night Sweats (sweating in night): 4 people, 36.36%
Hot Flush (sudden feelings of heat): 4 people, 36.36%
Thyroid Diseases: 2 people, 18.18%

* Approximation only. Some reports may have incomplete information.

Do you take Combipatch and have Application site warmth?

- Check whether Application site warmth is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Combipatch:

Combipatch (3,599 reports)

Application site warmth treatments and more:

Application site warmth (1,306 reports)

How severe was Application site warmth and when was it recovered:

Application site warmth in Combipatch

Expand to all the drugs that have ingredients of estradiol; norethindrone acetate:

Application site warmth and drugs with ingredients of estradiol; norethindrone acetate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Combipatch:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Application site warmth:

Application site warmth (106 drugs)

Browse all the conditions that are associated with Application site warmth:

Application site warmth (205 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol; norethindrone acetate (the active ingredients of Combipatch) and Combipatch (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.