Combipatch and Drug effect decreased - a phase IV clinical study of FDA data

Summary:

Drug effect decreased is reported as a side effect among people who take Combipatch (estradiol; norethindrone acetate), especially for people who are female, 50-59 old, also take Synthroid, and have Hot flush.

The phase IV clinical study analyzes which people have Drug effect decreased when taking Combipatch. It is created by eHealthMe based on reports of 3,544 people who have side effects when taking Combipatch from the FDA, and is updated regularly.

What is Combipatch?

Combipatch has active ingredients of estradiol; norethindrone acetate. It is often used in menopause. eHealthMe is studying from 3,599 Combipatch users. Check the latest studies of Combipatch.

What is Drug effect decreased?

Drug effect decreased is found to be associated with 1,458 drugs and 1,918 conditions by eHealthMe. Check the latest studies of Drug effect decreased.

On Jul, 13, 2026

3,544 people reported to have side effects when taking Combipatch.
Among them, 13 people (0.37%) have Drug effect decreased.

Could Combipatch cause Drug effect decreased?

Among these 13 people:

What is the gender of people who have Drug effect decreased when taking Combipatch? *

female: 100 %
male: 0.0 %

What is the age of people who have Drug effect decreased when taking Combipatch? *

What are other drugs people take besides Combipatch? *

What are other side effects people have besides Drug effect decreased? *

Insomnia (sleeplessness): 3 people, 23.08%
Fatigue (feeling of tiredness): 3 people, 23.08%
Dry Skin: 2 people, 15.38%
Vaginal Bleeding: 2 people, 15.38%
Trichorrhexis (a condition in which the hairs break): 2 people, 15.38%
Progesterone Increased: 2 people, 15.38%
Night Sweats (sweating in night): 2 people, 15.38%
Hot Flush (sudden feelings of heat): 2 people, 15.38%
Hair Texture Abnormal: 2 people, 15.38%
Hair Loss: 2 people, 15.38%

What are the existing conditions these people have? *

Hot Flush (sudden feelings of heat): 6 people, 46.15%
Night Sweats (sweating in night): 5 people, 38.46%
Thyroid Diseases: 2 people, 15.38%
Bone Loss: 2 people, 15.38%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 1 person, 7.69%
Incontinence (lack of moderation or self-control): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Combipatch and have Drug effect decreased?

- Check whether Drug effect decreased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Combipatch:

Combipatch (3,599 reports)

Drug effect decreased treatments and more:

Drug effect decreased (72,716 reports)

How severe was Drug effect decreased and when was it recovered:

Drug effect decreased in Combipatch

Expand to all the drugs that have ingredients of estradiol; norethindrone acetate:

Drug effect decreased and drugs with ingredients of estradiol; norethindrone acetate (22 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Combipatch:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Drug effect decreased:

Drug effect decreased (1,458 drugs)

Browse all the conditions that are associated with Drug effect decreased:

Drug effect decreased (1,918 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol; norethindrone acetate (the active ingredients of Combipatch) and Combipatch (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.