Combipatch and High blood cholesterol - a phase IV clinical study of FDA data

Summary:

High blood cholesterol is reported as a side effect among people who take Combipatch (estradiol; norethindrone acetate), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Prempro, and have Depression.

The phase IV clinical study analyzes which people have High blood cholesterol when taking Combipatch. It is created by eHealthMe based on reports of 3,544 people who have side effects when taking Combipatch from the FDA, and is updated regularly.

What is Combipatch?

Combipatch has active ingredients of estradiol; norethindrone acetate. It is often used in menopause. eHealthMe is studying from 3,599 Combipatch users. Check the latest studies of Combipatch.

What is High blood cholesterol?

High blood cholesterol is found to be associated with 2,273 drugs and 3,560 conditions by eHealthMe. Check the latest studies of High blood cholesterol.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

3,544 people reported to have side effects when taking Combipatch.
Among them, 40 people (1.13%) have High blood cholesterol.

Could Combipatch cause High blood cholesterol?

Among these 40 people:

How long have people been on Combipatch when they have High blood cholesterol? *

What is the gender of people who have High blood cholesterol when taking Combipatch? *

female: 100 %
male: 0.0 %

What is the age of people who have High blood cholesterol when taking Combipatch? *

What are other drugs people take besides Combipatch? *

What are other side effects people have besides High blood cholesterol? *

Breast Cancer: 22 people, 55.00%
High Blood Pressure: 20 people, 50.00%
Breast Lump (localized swelling that feels different from the surrounding breast tissue): 15 people, 37.50%
Cough: 14 people, 35.00%
Breast Pain: 14 people, 35.00%
Osteopenia (a condition where bone mineral density is lower than normal): 12 people, 30.00%
Rashes (redness): 12 people, 30.00%
Oestrogen Receptor Assay Positive: 12 people, 30.00%
Bone Density Decreased: 11 people, 27.50%
Nausea (feeling of having an urge to vomit): 11 people, 27.50%

What are the existing conditions these people have? *

Depression: 11 people, 27.50%
Vulvovaginal Dryness: 6 people, 15.00%
Sleep Disorder: 6 people, 15.00%
Hot Flush (sudden feelings of heat): 6 people, 15.00%
Bone Disorder: 4 people, 10.00%
Indigestion: 2 people, 5.00%
Cardiac Disorder: 2 people, 5.00%
Fatigue (feeling of tiredness): 2 people, 5.00%
Folliculitis (infection of hair root): 2 people, 5.00%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 2 people, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Combipatch and have High blood cholesterol?

- Check whether High blood cholesterol is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Combipatch:

Combipatch (3,599 reports)

High blood cholesterol treatments and more:

High blood cholesterol (478,592 reports)

How severe was High blood cholesterol and when was it recovered:

High blood cholesterol in Combipatch

Expand to all the drugs that have ingredients of estradiol; norethindrone acetate:

High blood cholesterol and drugs with ingredients of estradiol; norethindrone acetate (58 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Combipatch:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with High blood cholesterol:

High blood cholesterol (2,273 drugs)

Browse all the conditions that are associated with High blood cholesterol:

High blood cholesterol (3,560 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol; norethindrone acetate (the active ingredients of Combipatch) and Combipatch (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.