Combipatch and Itching - a phase IV clinical study of FDA data

Summary:

Itching is reported as a side effect among people who take Combipatch (estradiol; norethindrone acetate), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Aspirin, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Itching when taking Combipatch. It is created by eHealthMe based on reports of 3,544 people who have side effects when taking Combipatch from the FDA, and is updated regularly.

What is Combipatch?

Combipatch has active ingredients of estradiol; norethindrone acetate. It is often used in menopause. eHealthMe is studying from 3,599 Combipatch users. Check the latest studies of Combipatch.

What is Itching?

Itching is found to be associated with 3,218 drugs and 4,525 conditions by eHealthMe. Check the latest studies of Itching.

On Jan, 27, 2026

3,544 people reported to have side effects when taking Combipatch.
Among them, 49 people (1.38%) have Itching.

Among these 49 people:

How long have people been on Combipatch when they have Itching? *

What is the gender of people who have Itching when taking Combipatch? *

female: 100 %
male: 0.0 %

What is the age of people who have Itching when taking Combipatch? *

What are other drugs people take besides Combipatch? *

What are other side effects people have besides Itching? *

Rashes (redness): 18 people, 36.73%
Fatigue (feeling of tiredness): 13 people, 26.53%
Breast Cancer: 12 people, 24.49%
Pain: 11 people, 22.45%
Breast Pain: 10 people, 20.41%
Fall: 9 people, 18.37%
Insomnia (sleeplessness): 9 people, 18.37%
Osteoporosis (bones weak and more likely to break): 9 people, 18.37%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 9 people, 18.37%
Hot Flush (sudden feelings of heat): 8 people, 16.33%

What are the existing conditions these people have? *

High Blood Cholesterol: 8 people, 16.33%
Hypersensitivity: 7 people, 14.29%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 6 people, 12.24%
High Blood Pressure: 6 people, 12.24%
Stable Angina (a constant chest pain): 6 people, 12.24%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 6.12%
Hot Flush (sudden feelings of heat): 2 people, 4.08%
Migraine (headache): 2 people, 4.08%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 4.08%
Insomnia (sleeplessness): 2 people, 4.08%

* Approximation only. Some reports may have incomplete information.

Do you take Combipatch and have Itching?

- Check whether Itching is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Combipatch:

Combipatch (3,599 reports)

Itching treatments and more:

Itching (398,814 reports)

How severe was Itching and when was it recovered:

Itching in Combipatch

Expand to all the drugs that have ingredients of estradiol; norethindrone acetate:

Itching and drugs with ingredients of estradiol; norethindrone acetate (47 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Combipatch:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Itching:

Itching (3,218 drugs)

Browse all the conditions that are associated with Itching:

Itching (4,525 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol; norethindrone acetate (the active ingredients of Combipatch) and Combipatch (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.