Combipatch and Vaginal bleeding between periods - a phase IV clinical study of FDA data

Summary:

Vaginal bleeding between periods is reported as a side effect among people who take Combipatch (estradiol; norethindrone acetate), especially for people who are 50-59 old, have been taking the drug for 2 - 5 years also take Synthroid, and have Hot flush.

The phase IV clinical study analyzes which people have Vaginal bleeding between periods when taking Combipatch. It is created by eHealthMe based on reports of 3,544 people who have side effects when taking Combipatch from the FDA, and is updated regularly.

What is Combipatch?

Combipatch has active ingredients of estradiol; norethindrone acetate. It is often used in menopause. eHealthMe is studying from 3,599 Combipatch users. Check the latest studies of Combipatch.

What is Vaginal bleeding between periods?

Vaginal bleeding between periods is found to be associated with 577 drugs and 1,466 conditions by eHealthMe. Check the latest studies of Vaginal bleeding between periods.

On Jul, 04, 2026

3,544 people reported to have side effects when taking Combipatch.
Among them, 87 people (2.45%) have Vaginal bleeding between periods.

Could Combipatch cause Vaginal bleeding between periods?

Among these 87 people:

How long have people been on Combipatch when they have Vaginal bleeding between periods? *

What is the age of people who have Vaginal bleeding between periods when taking Combipatch? *

What are other drugs people take besides Combipatch? *

What are other side effects people have besides Vaginal bleeding between periods? *

Drug Ineffective: 10 people, 11.49%
Weakness: 10 people, 11.49%
Muscle Spasms (muscle contraction): 9 people, 10.34%
Hot Flush (sudden feelings of heat): 8 people, 9.20%
Nausea (feeling of having an urge to vomit): 8 people, 9.20%
Application Site Pruritus (application site severe itching of the skin): 8 people, 9.20%
Chest Pain: 8 people, 9.20%
Abdominal Distension: 8 people, 9.20%
Neck Pain: 6 people, 6.90%
Headache (pain in head): 6 people, 6.90%

What are the existing conditions these people have? *

Hot Flush (sudden feelings of heat): 23 people, 26.44%
Night Sweats (sweating in night): 10 people, 11.49%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 3 people, 3.45%
Thyroid Diseases: 3 people, 3.45%
Hypersensitivity: 2 people, 2.30%
Weakness: 2 people, 2.30%
Joint Pain: 2 people, 2.30%
Libido Disorder (a sexual dysfunction relating to loss of sexual desire): 2 people, 2.30%
Menstruation Irregular: 2 people, 2.30%
Fatigue (feeling of tiredness): 2 people, 2.30%

* Approximation only. Some reports may have incomplete information.

Do you take Combipatch and have Vaginal bleeding between periods?

- Check whether Vaginal bleeding between periods is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Combipatch:

Combipatch (3,599 reports)

Vaginal bleeding between periods treatments and more:

Vaginal bleeding between periods (26,954 reports)

How severe was Vaginal bleeding between periods and when was it recovered:

Vaginal bleeding between periods in Combipatch

Expand to all the drugs that have ingredients of estradiol; norethindrone acetate:

Vaginal bleeding between periods and drugs with ingredients of estradiol; norethindrone acetate (83 reports)

Sub-studies by age:

0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Combipatch:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Vaginal bleeding between periods:

Vaginal bleeding between periods (577 drugs)

Browse all the conditions that are associated with Vaginal bleeding between periods:

Vaginal bleeding between periods (1,466 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol; norethindrone acetate (the active ingredients of Combipatch) and Combipatch (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.