Combivent and Bone fragmentation - a phase IV clinical study of FDA data

Summary:

Bone fragmentation is reported as a side effect among people who take Combivent (albuterol sulfate; ipratropium bromide), especially for people who are male, 60+ old, also take Aredia, and have Metastases to bone.

The phase IV clinical study analyzes which people have Bone fragmentation when taking Combivent. It is created by eHealthMe based on reports of 35,104 people who have side effects when taking Combivent from the FDA, and is updated regularly.

What is Combivent?

Combivent has active ingredients of albuterol sulfate; ipratropium bromide. It is often used in asthma. eHealthMe is studying from 35,341 Combivent users. Check the latest studies of Combivent.

What is Bone fragmentation?

Bone fragmentation is found to be associated with 358 drugs and 245 conditions by eHealthMe. Check the latest studies of Bone fragmentation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

35,104 people reported to have side effects when taking Combivent.
Among them, 24 people (0.07%) have Bone fragmentation.

Could Combivent cause Bone fragmentation?

Among these 24 people:

What is the gender of people who have Bone fragmentation when taking Combivent? *

female: 39.13 %
male: 60.87 %

What is the age of people who have Bone fragmentation when taking Combivent? *

What are other drugs people take besides Combivent? *

What are other side effects people have besides Bone fragmentation? *

Osteonecrosis Of Jaw (death of bone of jaw): 24 people, 100.00%
Pneumonia: 23 people, 95.83%
Dyspnea (difficult or laboured breathing): 23 people, 95.83%
Pain In Jaw: 21 people, 87.50%
Osteomyelitis (infection of bone): 19 people, 79.17%
Bone Disorder: 19 people, 79.17%
Osteolysis (dissolution of bone): 18 people, 75.00%
Fall: 18 people, 75.00%
Impaired Healing: 18 people, 75.00%
Constipation: 18 people, 75.00%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 19 people, 79.17%
Traumatic Injury Of The Bladder And Urethra: 7 people, 29.17%
Lung Neoplasm Malignant (cancer tumour of lung): 3 people, 12.50%
Multiple Myeloma (cancer of the plasma cells): 2 people, 8.33%
Pain: 1 person, 4.17%
Metastases To Pelvis (cancer spreads to pelvis): 1 person, 4.17%
Hypercalcaemia Of Malignancy (elevated calcium (ca+) level in the blood with cancer): 1 person, 4.17%
High Blood Cholesterol: 1 person, 4.17%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 1 person, 4.17%
Acute Coronary Syndrome (acute chest pain and other symptoms that happen because the heart does not get blood): 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Combivent and have Bone fragmentation?

- Check whether Bone fragmentation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Combivent:

Combivent (35,341 reports)

Bone fragmentation treatments and more:

Bone fragmentation (1,053 reports)

How severe was Bone fragmentation and when was it recovered:

Bone fragmentation in Combivent

Expand to all the drugs that have ingredients of albuterol sulfate; ipratropium bromide:

Bone fragmentation and drugs with ingredients of albuterol sulfate; ipratropium bromide

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Combivent:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Bone fragmentation:

Bone fragmentation (358 drugs)

Browse all the conditions that are associated with Bone fragmentation:

Bone fragmentation (245 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on albuterol sulfate; ipratropium bromide (the active ingredients of Combivent) and Combivent (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.