Lamotrigine and Hyponatremia - a phase IV clinical study of FDA data

Summary:

Hyponatremia is reported as a side effect among people who take Lamotrigine (lamotrigine), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Levetiracetam, and have Depression.

The phase IV clinical study analyzes which people have Hyponatremia when taking Lamotrigine. It is created by eHealthMe based on reports of 72,834 people who have side effects when taking Lamotrigine from the FDA, and is updated regularly.

What is Lamotrigine?

Lamotrigine has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 76,638 Lamotrigine users. Check the latest studies of Lamotrigine.

What is Hyponatremia?

Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration) is found to be associated with 1,937 drugs and 2,272 conditions by eHealthMe. Check the latest studies of Hyponatremia.

On May, 11, 2026

72,834 people reported to have side effects when taking Lamotrigine.
Among them, 500 people (0.69%) have Hyponatremia.

Among these 500 people:

* Approximation only. Some reports may have incomplete information.

Do you take Lamotrigine and have Hyponatremia?

- Check whether Hyponatremia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Lamotrigine:

Lamotrigine (76,638 reports)

Hyponatremia treatments and more:

Hyponatremia (72,436 reports)

How severe was Hyponatremia and when was it recovered:

Hyponatremia in Lamotrigine

Expand to all the drugs that have ingredients of lamotrigine:

Hyponatremia and drugs with ingredients of lamotrigine (887 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Lamotrigine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyponatremia:

Hyponatremia (1,937 drugs)

Browse all the conditions that are associated with Hyponatremia:

Hyponatremia (2,272 conditions)

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on lamotrigine (the active ingredients of Lamotrigine) and Lamotrigine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.