Contac and Atrial fibrillation/flutter - a phase IV clinical study of FDA data

Summary:

Atrial fibrillation/flutter is reported as a side effect among people who take Contac (chlorpheniramine maleate; phenylpropanolamine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Dimetapp, and have Nasopharyngitis.

The phase IV clinical study analyzes which people have Atrial fibrillation/flutter when taking Contac. It is created by eHealthMe based on reports of 2,867 people who have side effects when taking Contac from the FDA, and is updated regularly.

What is Contac?

Contac has active ingredients of chlorpheniramine maleate; phenylpropanolamine hydrochloride. eHealthMe is studying from 2,877 Contac users. Check the latest studies of Contac.

What is Atrial fibrillation/flutter?

Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles) is found to be associated with 2,364 drugs and 3,841 conditions by eHealthMe. Check the latest studies of Atrial fibrillation/flutter.

On Apr, 30, 2026

2,867 people reported to have side effects when taking Contac.
Among them, 11 people (0.38%) have Atrial fibrillation/flutter.

Could Contac cause Atrial fibrillation/flutter?

Among these 11 people:

How long have people been on Contac when they have Atrial fibrillation/flutter? *

What is the gender of people who have Atrial fibrillation/flutter when taking Contac? *

female: 63.64 %
male: 36.36 %

What is the age of people who have Atrial fibrillation/flutter when taking Contac? *

What are other drugs people take besides Contac? *

Raloxifene Hydrochloride: 3 people, 27.27%
Garlic: 3 people, 27.27%
Dimetapp: 3 people, 27.27%
Robitussin: 2 people, 18.18%
Lasix: 2 people, 18.18%
Hydrocortisone: 2 people, 18.18%
Indapamide: 1 person, 9.09%

What are other side effects people have besides Atrial fibrillation/flutter? *

Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 5 people, 45.45%
Head Injury: 3 people, 27.27%
Carotid Artery Occlusion (artery blockage): 3 people, 27.27%
Fall: 3 people, 27.27%
Injury: 3 people, 27.27%
Lung Cancer Stage Unspecified (Exc Metastatic Tumors To Lung): 3 people, 27.27%
Cerebral Atrophy (decrement in size of brain): 3 people, 27.27%
Haemorrhagic Stroke (stroke caused by the rupture of a blood vessel in the brain): 2 people, 18.18%
Nodal Arrhythmia (an irregular heart beat originating from within the atrioventricular node): 2 people, 18.18%
Stress And Anxiety: 2 people, 18.18%

What are the existing conditions these people have? *

Nasopharyngitis (inflammation of the nasopharynx): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Contac and have Atrial fibrillation/flutter?

- Check whether Atrial fibrillation/flutter is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Contac:

Contac (2,877 reports)

Atrial fibrillation/flutter treatments and more:

Atrial fibrillation/flutter (349,226 reports)

How severe was Atrial fibrillation/flutter and when was it recovered:

Atrial fibrillation/flutter in Contac

Expand to all the drugs that have ingredients of chlorpheniramine maleate; phenylpropanolamine hydrochloride:

Atrial fibrillation/flutter and drugs with ingredients of chlorpheniramine maleate; phenylpropanolamine hydrochloride (133 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Contac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Atrial fibrillation/flutter:

Atrial fibrillation/flutter (2,364 drugs)

Browse all the conditions that are associated with Atrial fibrillation/flutter:

Atrial fibrillation/flutter (3,841 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on chlorpheniramine maleate; phenylpropanolamine hydrochloride (the active ingredients of Contac) and Contac (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.