Contrave and Muscle twitching - a phase IV clinical study of FDA data

Summary:

Muscle twitching is reported as a side effect among people who take Contrave (bupropion hydrochloride; naltrexone hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Metformin, and have Diabetes.

The phase IV clinical study analyzes which people have Muscle twitching when taking Contrave. It is created by eHealthMe based on reports of 5,301 people who have side effects when taking Contrave from the FDA, and is updated regularly.

What is Contrave?

Contrave has active ingredients of bupropion hydrochloride; naltrexone hydrochloride. It is often used in weight loss. eHealthMe is studying from 5,553 Contrave users. Check the latest studies of Contrave.

What is Muscle twitching?

Muscle twitching is found to be associated with 1,235 drugs and 1,906 conditions by eHealthMe. Check the latest studies of Muscle twitching.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

5,301 people reported to have side effects when taking Contrave.
Among them, 30 people (0.57%) have Muscle twitching.

Among these 30 people:

How long have people been on Contrave when they have Muscle twitching? *

What is the gender of people who have Muscle twitching when taking Contrave? *

female: 80 %
male: 20 %

What is the age of people who have Muscle twitching when taking Contrave? *

What are other drugs people take besides Contrave? *

What are other side effects people have besides Muscle twitching? *

Nausea (feeling of having an urge to vomit): 10 people, 33.33%
Back Pain: 9 people, 30.00%
Insomnia (sleeplessness): 8 people, 26.67%
Constipation: 7 people, 23.33%
Joint Pain: 6 people, 20.00%
Dizziness: 6 people, 20.00%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 5 people, 16.67%
Depression: 5 people, 16.67%
Sleep Disorder: 5 people, 16.67%
Stress And Anxiety: 5 people, 16.67%

What are the existing conditions these people have? *

Depression: 9 people, 30.00%
Diabetes: 9 people, 30.00%
High Blood Pressure: 5 people, 16.67%
Weight Decreased: 5 people, 16.67%
High Blood Cholesterol: 4 people, 13.33%
Blood Testosterone Free Decreased: 4 people, 13.33%
Poor Quality Sleep: 3 people, 10.00%
Insomnia (sleeplessness): 2 people, 6.67%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 6.67%
Pain: 2 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Contrave and have Muscle twitching?

- Check whether Muscle twitching is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Contrave:

Contrave (5,553 reports)

Muscle twitching treatments and more:

Muscle twitching (29,030 reports)

How severe was Muscle twitching and when was it recovered:

Muscle twitching in Contrave

Expand to all the drugs that have ingredients of bupropion hydrochloride; naltrexone hydrochloride:

Muscle twitching and drugs with ingredients of bupropion hydrochloride; naltrexone hydrochloride (31 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Contrave:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Muscle twitching:

Muscle twitching (1,235 drugs)

Browse all the conditions that are associated with Muscle twitching:

Muscle twitching (1,906 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on bupropion hydrochloride; naltrexone hydrochloride (the active ingredients of Contrave) and Contrave (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.