Contrave and Suicidal ideation - a phase IV clinical study of FDA data

Summary:

Suicidal ideation is reported as a side effect among people who take Contrave (bupropion hydrochloride; naltrexone hydrochloride), especially for people who are female, 40-49 old, have been taking the drug for < 1 month also take Adderall, and have Weight decreased.

The phase IV clinical study analyzes which people have Suicidal ideation when taking Contrave. It is created by eHealthMe based on reports of 5,301 people who have side effects when taking Contrave from the FDA, and is updated regularly.

What is Contrave?

Contrave has active ingredients of bupropion hydrochloride; naltrexone hydrochloride. It is often used in weight loss. eHealthMe is studying from 5,553 Contrave users. Check the latest studies of Contrave.

What is Suicidal ideation?

Suicidal ideation is found to be associated with 1,978 drugs and 2,343 conditions by eHealthMe. Check the latest studies of Suicidal ideation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

5,301 people reported to have side effects when taking Contrave.
Among them, 95 people (1.79%) have Suicidal ideation.

Among these 95 people:

How long have people been on Contrave when they have Suicidal ideation? *

What is the gender of people who have Suicidal ideation when taking Contrave? *

female: 86.67 %
male: 13.33 %

What is the age of people who have Suicidal ideation when taking Contrave? *

What are other drugs people take besides Contrave? *

What are other side effects people have besides Suicidal ideation? *

Depression: 20 people, 21.05%
Stress And Anxiety: 20 people, 21.05%
Nausea (feeling of having an urge to vomit): 15 people, 15.79%
Feeling Abnormal: 11 people, 11.58%
Dizziness: 10 people, 10.53%
Depressed Mood: 8 people, 8.42%
Dry Mouth: 8 people, 8.42%
Fatigue (feeling of tiredness): 8 people, 8.42%
Headache (pain in head): 7 people, 7.37%
Diarrhea: 6 people, 6.32%

What are the existing conditions these people have? *

Weight Decreased: 14 people, 14.74%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 6.32%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 5.26%
High Blood Pressure: 4 people, 4.21%
Depression: 4 people, 4.21%
Insomnia (sleeplessness): 4 people, 4.21%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 3 people, 3.16%
Binge Eating (pattern of disordered eating which consists of episodes of uncontrollable eating): 3 people, 3.16%
Respiratory Disorder (respiratory disease): 3 people, 3.16%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 3.16%

* Approximation only. Some reports may have incomplete information.

Do you take Contrave and have Suicidal ideation?

- Check whether Suicidal ideation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Contrave:

Contrave (5,553 reports)

Suicidal ideation treatments and more:

Suicidal ideation (109,012 reports)

How severe was Suicidal ideation and when was it recovered:

Suicidal ideation in Contrave

Expand to all the drugs that have ingredients of bupropion hydrochloride; naltrexone hydrochloride:

Suicidal ideation and drugs with ingredients of bupropion hydrochloride; naltrexone hydrochloride (76 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Contrave:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Suicidal ideation:

Suicidal ideation (1,978 drugs)

Browse all the conditions that are associated with Suicidal ideation:

Suicidal ideation (2,343 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on bupropion hydrochloride; naltrexone hydrochloride (the active ingredients of Contrave) and Contrave (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.