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Cordarone and Listless - a phase IV clinical study of FDA data

Summary:

Listless is reported as a side effect among people who take Cordarone (amiodarone hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Euthyrox, and have Pain.

The phase IV clinical study analyzes which people have Listless when taking Cordarone. It is created by eHealthMe based on reports of 22,652 people who have side effects when taking Cordarone from the FDA, and is updated regularly.

What is Cordarone?

Cordarone has active ingredients of amiodarone hydrochloride. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 22,776 Cordarone users. Check the latest studies of Cordarone.

What is Listless?

Listless (lack of interest, energy, or spirit) is found to be associated with 461 drugs and 651 conditions by eHealthMe. Check the latest studies of Listless.

On Jul, 09, 2026

22,652 people reported to have side effects when taking Cordarone.
Among them, 71 people (0.31%) have Listless.

Could Cordarone cause Listless?

Among these 71 people:

How long have people been on Cordarone when they have Listless? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 100 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Listless when taking Cordarone? *

  • female: 97.18 %
  • male: 2.82 %

What is the age of people who have Listless when taking Cordarone? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 2.86 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 97.14 %

What are other drugs people take besides Cordarone? *

  1. Euthyrox: 68 people, 95.77%
  2. Eliquis: 66 people, 92.96%
  3. Panadol: 61 people, 85.92%
  4. Potassium Aspartate: 57 people, 80.28%
  5. Magnesium Aspartate: 49 people, 69.01%
  6. Pantoprazole: 27 people, 38.03%
  7. Zolpidem Tartrate: 26 people, 36.62%
  8. Prednisone: 26 people, 36.62%
  9. Amlodipine Besylate: 26 people, 36.62%
  10. Fentanyl: 26 people, 36.62%

What are other side effects people have besides Listless? *

  1. Delirium (wild excitement): 69 people, 97.18%
  2. Dizziness: 69 people, 97.18%
  3. Urinary Retention (the inability to completely or partially empty the bladder): 69 people, 97.18%
  4. Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 69 people, 97.18%
  5. Apathy: 69 people, 97.18%
  6. Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 69 people, 97.18%
  7. Confusional State: 69 people, 97.18%
  8. Oxygen Saturation Decreased: 69 people, 97.18%
  9. Head Discomfort: 69 people, 97.18%
  10. Nausea (feeling of having an urge to vomit): 69 people, 97.18%

What are the existing conditions these people have? *

  1. Pain: 69 people, 97.18%
  2. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 68 people, 95.77%
  3. Chronic Thyroiditis (long lasting inflammation of thyroid gland): 68 people, 95.77%
  4. Post Herpetic Neuralgia (neuralgia caused by the varicella zoster virus): 67 people, 94.37%
  5. Constipation: 67 people, 94.37%
  6. High Blood Pressure: 52 people, 73.24%
  7. Encephalopathy (functioning of the brain is affected by some agent or condition): 48 people, 67.61%
  8. Calcium Deficiency (lack of calcium): 47 people, 66.20%
  9. Nausea (feeling of having an urge to vomit): 46 people, 64.79%
  10. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 13 people, 18.31%

* Approximation only. Some reports may have incomplete information.

Do you take Cordarone and have Listless?

- Check whether Listless is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cordarone:

Listless treatments and more:

How severe was Listless and when was it recovered:

Expand to all the drugs that have ingredients of amiodarone hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cordarone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Listless:

Browse all the conditions that are associated with Listless:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on amiodarone hydrochloride (the active ingredients of Cordarone) and Cordarone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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