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Cordarone and Lymphoedema - a phase IV clinical study of FDA data

Summary:

Lymphoedema is reported as a side effect among people who take Cordarone (amiodarone hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months also take Amlodipine, and have High blood pressure.

The phase IV clinical study analyzes which people have Lymphoedema when taking Cordarone. It is created by eHealthMe based on reports of 22,652 people who have side effects when taking Cordarone from the FDA, and is updated regularly.

What is Cordarone?

Cordarone has active ingredients of amiodarone hydrochloride. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 22,776 Cordarone users. Check the latest studies of Cordarone.

What is Lymphoedema?

Lymphoedema (localized fluid retention and tissue swelling) is found to be associated with 912 drugs and 743 conditions by eHealthMe. Check the latest studies of Lymphoedema.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

22,652 people reported to have side effects when taking Cordarone.
Among them, 14 people (0.06%) have Lymphoedema.

Could Cordarone cause Lymphoedema?

Among these 14 people:

How long have people been on Cordarone when they have Lymphoedema? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 100 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Lymphoedema when taking Cordarone? *

  • female: 66.67 %
  • male: 33.33 %

What is the age of people who have Lymphoedema when taking Cordarone? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 10 %
  • 60+: 90 %

What are other drugs people take besides Cordarone? *

  1. Diclofenac: 7 people, 50.00%
  2. Amlodipine: 7 people, 50.00%
  3. Accupril: 3 people, 21.43%
  4. Lasix: 3 people, 21.43%
  5. Taxotere: 2 people, 14.29%
  6. Micro-K: 2 people, 14.29%
  7. Heparin: 2 people, 14.29%
  8. Digoxin: 2 people, 14.29%
  9. Carboplatin: 2 people, 14.29%
  10. Coumadin: 2 people, 14.29%

What are other side effects people have besides Lymphoedema? *

  1. Cardiac Failure Congestive: 4 people, 28.57%
  2. Hypokalemia (low potassium): 3 people, 21.43%
  3. Fatigue (feeling of tiredness): 3 people, 21.43%
  4. Weakness: 3 people, 21.43%
  5. Nausea (feeling of having an urge to vomit): 3 people, 21.43%
  6. Atelectasis (partial or complete collapse of the lung): 3 people, 21.43%
  7. Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 3 people, 21.43%
  8. Dyspnea (difficult or laboured breathing): 3 people, 21.43%
  9. Bundle Branch Block Left (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the left ventricle): 3 people, 21.43%
  10. Ischaemic Cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease): 2 people, 14.29%

What are the existing conditions these people have? *

  1. High Blood Pressure: 7 people, 50.00%
  2. Lung Cancer - Non-Small Cell (lung cancer): 2 people, 14.29%
  3. Ventricular Dysfunction (heart dysfunction): 1 person, 7.14%
  4. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 7.14%
  5. Renal Cancer Metastatic (cancer of kidney spreads to other part): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Cordarone and have Lymphoedema?

- Check whether Lymphoedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cordarone:

Lymphoedema treatments and more:

How severe was Lymphoedema and when was it recovered:

Expand to all the drugs that have ingredients of amiodarone hydrochloride:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cordarone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Lymphoedema:

Browse all the conditions that are associated with Lymphoedema:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on amiodarone hydrochloride (the active ingredients of Cordarone) and Cordarone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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