Wellbutrin sr and Mania aggravated - a phase IV clinical study of FDA data

Summary:

Mania aggravated is reported as a side effect among people who take Wellbutrin sr (bupropion hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for 2 - 5 years also take Prozac, and have Bipolar disorder.

The phase IV clinical study analyzes which people have Mania aggravated when taking Wellbutrin sr. It is created by eHealthMe based on reports of 9,388 people who have side effects when taking Wellbutrin sr from the FDA, and is updated regularly.

What is Wellbutrin sr?

Wellbutrin sr has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 13,112 Wellbutrin sr users. Check the latest studies of Wellbutrin sr.

What is Mania aggravated?

Mania aggravated (irritable mood) is found to be associated with 815 drugs and 375 conditions by eHealthMe. Check the latest studies of Mania aggravated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

9,388 people reported to have side effects when taking Wellbutrin sr.
Among them, 45 people (0.48%) have Mania aggravated.

Could Wellbutrin sr cause Mania aggravated?

Among these 45 people:

How long have people been on Wellbutrin sr when they have Mania aggravated? *

What is the gender of people who have Mania aggravated when taking Wellbutrin sr? *

female: 72.73 %
male: 27.27 %

What is the age of people who have Mania aggravated when taking Wellbutrin sr? *

What are other drugs people take besides Wellbutrin sr? *

What are other side effects people have besides Mania aggravated? *

Insomnia (sleeplessness): 13 people, 28.89%
Suicidal Ideation: 9 people, 20.00%
Agitation (state of anxiety or nervous excitement): 9 people, 20.00%
Malaise (a feeling of general discomfort or uneasiness): 8 people, 17.78%
Memory Loss: 7 people, 15.56%
Aggression: 7 people, 15.56%
Feeling Abnormal: 6 people, 13.33%
Fatigue (feeling of tiredness): 5 people, 11.11%
Performance Status Decreased: 5 people, 11.11%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 5 people, 11.11%

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 15 people, 33.33%
Multiple Myeloma (cancer of the plasma cells): 4 people, 8.89%
Headache (pain in head): 3 people, 6.67%
Bipolar Ii Disorder (characterized by at least one episode of hypomania and at least one episode of major depression): 3 people, 6.67%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 4.44%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 2 people, 4.44%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 2 people, 4.44%
Sleep Disorder: 1 person, 2.22%
Quit Smoking: 1 person, 2.22%
Psychotic Disorder: 1 person, 2.22%

* Approximation only. Some reports may have incomplete information.

Do you take Wellbutrin sr and have Mania aggravated?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Wellbutrin sr:

Wellbutrin sr (13,112 reports)

Browse all side effects of Wellbutrin sr:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mania aggravated:

Mania aggravated (815 drugs)

Browse all the conditions that are associated with Mania aggravated:

Mania aggravated (375 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on bupropion hydrochloride (the active ingredients of Wellbutrin sr) and Wellbutrin sr (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.