Coreg and Cytokine release syndrome - a phase IV clinical study of FDA data

Summary:

Cytokine release syndrome is reported as a side effect among people who take Coreg (carvedilol), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Zofran, and have Non-hodgkin's lymphoma.

The phase IV clinical study analyzes which people have Cytokine release syndrome when taking Coreg. It is created by eHealthMe based on reports of 48,155 people who have side effects when taking Coreg from the FDA, and is updated regularly.

What is Coreg?

Coreg has active ingredients of carvedilol. It is often used in high blood pressure. eHealthMe is studying from 49,583 Coreg users. Check the latest studies of Coreg.

What is Cytokine release syndrome?

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions) is found to be associated with 518 drugs and 455 conditions by eHealthMe. Check the latest studies of Cytokine release syndrome.

On Jul, 18, 2026

48,155 people reported to have side effects when taking Coreg.
Among them, 12 people (0.02%) have Cytokine release syndrome.

Could Coreg cause Cytokine release syndrome?

Among these 12 people:

How long have people been on Coreg when they have Cytokine release syndrome? *

What is the gender of people who have Cytokine release syndrome when taking Coreg? *

female: 8.33 %
male: 91.67 %

What is the age of people who have Cytokine release syndrome when taking Coreg? *

What are other drugs people take besides Coreg? *

What are other side effects people have besides Cytokine release syndrome? *

Fever: 8 people, 66.67%
Hypotension (abnormally low blood pressure): 6 people, 50.00%
Neurotoxicity (when the exposure to natural or artificial toxic substances, which are called neurotoxins, alters the normal activity of the nervous system): 4 people, 33.33%
Chills (felling of cold): 4 people, 33.33%
Encephalopathy (functioning of the brain is affected by some agent or condition): 4 people, 33.33%
Confusional State: 3 people, 25.00%
Nausea And Vomiting: 3 people, 25.00%
Arrhythmias (irregular heartbeat): 3 people, 25.00%
Sepsis (a severe blood infection that can lead to organ failure and death): 3 people, 25.00%
Pleural Effusion (water on the lungs): 3 people, 25.00%

What are the existing conditions these people have? *

Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 6 people, 50.00%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 3 people, 25.00%
Insomnia (sleeplessness): 3 people, 25.00%
Pain: 2 people, 16.67%
Agitation (state of anxiety or nervous excitement): 2 people, 16.67%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 2 people, 16.67%
Diffuse Large B-Cell Lymphoma Recurrent (recurrent cancer of b cells, a type of white blood cell): 2 people, 16.67%
Dry Eyes (lack of adequate tears): 2 people, 16.67%
Dry Skin: 2 people, 16.67%
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough): 2 people, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Coreg and have Cytokine release syndrome?

- Check whether Cytokine release syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Coreg:

Coreg (49,583 reports)

Browse all side effects of Coreg:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cytokine release syndrome:

Cytokine release syndrome (518 drugs)

Browse all the conditions that are associated with Cytokine release syndrome:

Cytokine release syndrome (455 conditions)

Related publications that referenced our studies

Barold, S. S., & Upton, S. , "Hyperkalemia Induced by the Sequential Administration of Metoprolol and Carvedilol", Case reports in cardiology, 2018 Jan .
Kim MS, Baek IH, "Effect of dronedarone on the pharmacokinetics of carvedilol following oral administration to rats", European Journal of Pharmaceutical Sciences, 2018 Jan .
Barold, S. S., & Upton, S. , "Hyperkalemia Induced by the Sequential Administration of Metoprolol and Carvedilol", Case reports in cardiology, 2018 Jan .
Kim MS, Baek IH, "Effect of dronedarone on the pharmacokinetics of carvedilol following oral administration to rats", European Journal of Pharmaceutical Sciences, 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on carvedilol (the active ingredients of Coreg) and Coreg (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.