Cosopt and Atherosclerosis - a phase IV clinical study of FDA data

Summary:

Atherosclerosis is reported as a side effect among people who take Cosopt (dorzolamide hydrochloride; timolol maleate), especially for people who are male, 60+ old, have been taking the drug for 10+ years also take Hydrochlorothiazide, and have Metastases to bone.

The phase IV clinical study analyzes which people have Atherosclerosis when taking Cosopt. It is created by eHealthMe based on reports of 8,872 people who have side effects when taking Cosopt from the FDA, and is updated regularly.

What is Cosopt?

Cosopt has active ingredients of dorzolamide hydrochloride; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 9,029 Cosopt users. Check the latest studies of Cosopt.

What is Atherosclerosis?

Atherosclerosis (disorder of the arteries) is found to be associated with 1,199 drugs and 1,533 conditions by eHealthMe. Check the latest studies of Atherosclerosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

8,872 people reported to have side effects when taking Cosopt.
Among them, 15 people (0.17%) have Atherosclerosis.

Among these 15 people:

How long have people been on Cosopt when they have Atherosclerosis? *

What is the gender of people who have Atherosclerosis when taking Cosopt? *

female: 46.67 %
male: 53.33 %

What is the age of people who have Atherosclerosis when taking Cosopt? *

What are other drugs people take besides Cosopt? *

What are other side effects people have besides Atherosclerosis? *

Pain: 9 people, 60.00%
Cardiac Failure Congestive: 9 people, 60.00%
Weakness: 8 people, 53.33%
Cough: 8 people, 53.33%
Arrhythmias (irregular heartbeat): 8 people, 53.33%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 8 people, 53.33%
Wheezing (a high-pitched whistling sound made while you breath): 7 people, 46.67%
Mitral Valve Incompetence (inefficient heart valve): 7 people, 46.67%
Osteonecrosis Of Jaw (death of bone of jaw): 7 people, 46.67%
Deformity (disfigurement): 7 people, 46.67%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 4 people, 26.67%
Breast Cancer: 3 people, 20.00%
Multiple Myeloma (cancer of the plasma cells): 2 people, 13.33%
Lung Cancer - Non-Small Cell (lung cancer): 2 people, 13.33%
High Blood Cholesterol: 2 people, 13.33%
Uveitis (inflammation of the uvea): 1 person, 6.67%
Paget's Disease (disorder that involves abnormal bone destruction and regrowth, which results in deformity): 1 person, 6.67%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 6.67%
Eye Disorder: 1 person, 6.67%
Depression: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Cosopt and have Atherosclerosis?

- Check whether Atherosclerosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cosopt:

Cosopt (9,029 reports)

Atherosclerosis treatments and more:

Atherosclerosis (21,888 reports)

How severe was Atherosclerosis and when was it recovered:

Atherosclerosis in Cosopt

Expand to all the drugs that have ingredients of dorzolamide hydrochloride; timolol maleate:

Atherosclerosis and drugs with ingredients of dorzolamide hydrochloride; timolol maleate (16 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cosopt:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Atherosclerosis:

Atherosclerosis (1,199 drugs)

Browse all the conditions that are associated with Atherosclerosis:

Atherosclerosis (1,533 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on dorzolamide hydrochloride; timolol maleate (the active ingredients of Cosopt) and Cosopt (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.