Cosopt and Hepatic failure - a phase IV clinical study of FDA data

Summary:

Hepatic failure is reported as a side effect among people who take Cosopt (dorzolamide hydrochloride; timolol maleate), especially for people who are male, 60+ old, also take Xalatan, and have Gastroesophageal reflux disease.

The phase IV clinical study analyzes which people have Hepatic failure when taking Cosopt. It is created by eHealthMe based on reports of 8,872 people who have side effects when taking Cosopt from the FDA, and is updated regularly.

What is Cosopt?

Cosopt has active ingredients of dorzolamide hydrochloride; timolol maleate. It is often used in glaucoma. eHealthMe is studying from 9,029 Cosopt users. Check the latest studies of Cosopt.

What is Hepatic failure?

Hepatic failure (liver failure) is found to be associated with 1,539 drugs and 1,894 conditions by eHealthMe. Check the latest studies of Hepatic failure.

On Aug, 06, 2026

8,872 people reported to have side effects when taking Cosopt.
Among them, 24 people (0.27%) have Hepatic failure.

Among these 24 people:

What is the gender of people who have Hepatic failure when taking Cosopt? *

female: 29.17 %
male: 70.83 %

What is the age of people who have Hepatic failure when taking Cosopt? *

What are other drugs people take besides Cosopt? *

What are other side effects people have besides Hepatic failure? *

Nausea (feeling of having an urge to vomit): 7 people, 29.17%
Jaundice - Yellow Skin (a yellowish pigmentation of the skin): 5 people, 20.83%
Abdominal Pain Upper: 5 people, 20.83%
Hepatitis (inflammation of the liver): 5 people, 20.83%
Gallbladder Disorder: 4 people, 16.67%
Itching: 4 people, 16.67%
International Normalised Ratio Decreased: 4 people, 16.67%
Carbon Dioxide Decreased: 4 people, 16.67%
Chest Pain: 4 people, 16.67%
Chills (felling of cold): 4 people, 16.67%

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 29.17%
Groin Pain: 4 people, 16.67%
Stomatitis (inflammation of mucous membrane of mouth): 4 people, 16.67%
Prostate Cancer: 4 people, 16.67%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 4 people, 16.67%
Osteitis (a general term for inflammation of bone): 4 people, 16.67%
Metastases To Bone (cancer spreads to bone): 4 people, 16.67%
Constipation: 4 people, 16.67%
Depression: 4 people, 16.67%
Stress And Anxiety: 4 people, 16.67%

* Approximation only. Some reports may have incomplete information.

Do you take Cosopt and have Hepatic failure?

- Check whether Hepatic failure is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cosopt:

Cosopt (9,029 reports)

Hepatic failure treatments and more:

Hepatic failure (44,058 reports)

How severe was Hepatic failure and when was it recovered:

Hepatic failure in Cosopt

Expand to all the drugs that have ingredients of dorzolamide hydrochloride; timolol maleate:

Hepatic failure and drugs with ingredients of dorzolamide hydrochloride; timolol maleate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cosopt:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatic failure:

Hepatic failure (1,539 drugs)

Browse all the conditions that are associated with Hepatic failure:

Hepatic failure (1,894 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on dorzolamide hydrochloride; timolol maleate (the active ingredients of Cosopt) and Cosopt (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.