Cotrim and Lymphopenia - a phase IV clinical study of FDA data

Summary:

Lymphopenia is reported as a side effect among people who take Cotrim (sulfamethoxazole; trimethoprim), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Cyclophosphamide, and have Burkitt lymphoma.

The phase IV clinical study analyzes which people have Lymphopenia when taking Cotrim. It is created by eHealthMe based on reports of 8,881 people who have side effects when taking Cotrim from the FDA, and is updated regularly.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

What is Lymphopenia?

Lymphopenia (an abnormally low level of lymphocytes in the blood) is found to be associated with 889 drugs and 1,078 conditions by eHealthMe. Check the latest studies of Lymphopenia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

8,881 people reported to have side effects when taking Cotrim.
Among them, 48 people (0.54%) have Lymphopenia.

Among these 48 people:

How long have people been on Cotrim when they have Lymphopenia? *

What is the gender of people who have Lymphopenia when taking Cotrim? *

female: 67.57 %
male: 32.43 %

What is the age of people who have Lymphopenia when taking Cotrim? *

What are other drugs people take besides Cotrim? *

What are other side effects people have besides Lymphopenia? *

Fever: 17 people, 35.42%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 17 people, 35.42%
Thrombocytopenia (decrease of platelets in blood): 15 people, 31.25%
Anaemia (lack of blood): 8 people, 16.67%
Blood Lactate Dehydrogenase Increased: 6 people, 12.50%
Pleural Effusion (water on the lungs): 5 people, 10.42%
Epstein-Barr Virus Infection: 5 people, 10.42%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 5 people, 10.42%
Cytomegalovirus Infection: 5 people, 10.42%
Nausea And Vomiting: 5 people, 10.42%

What are the existing conditions these people have? *

Burkitt Lymphoma (cancer of the lymphatic system): 6 people, 12.50%
T-Cell Lymphoma (a blood cell cancer): 5 people, 10.42%
Acute Myeloid Leukaemia Recurrent (acute cancer in which the bone marrow makes abnormal myeloblast- recurrent): 4 people, 8.33%
Multiple Myeloma (cancer of the plasma cells): 4 people, 8.33%
Follicle Centre Lymphoma, Follicular Grade I, Ii, Iii: 3 people, 6.25%
Adverse Event: 3 people, 6.25%
Arrhythmias (irregular heartbeat): 3 people, 6.25%
Pulmonary Embolism (blockage of the main artery of the lung): 3 people, 6.25%
Depression: 3 people, 6.25%
Insomnia (sleeplessness): 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Cotrim and have Lymphopenia?

- Check whether Lymphopenia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cotrim:

Cotrim (8,890 reports)

Lymphopenia treatments and more:

Lymphopenia (16,935 reports)

How severe was Lymphopenia and when was it recovered:

Lymphopenia in Cotrim

Expand to all the drugs that have ingredients of sulfamethoxazole; trimethoprim:

Lymphopenia and drugs with ingredients of sulfamethoxazole; trimethoprim (1,019 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cotrim:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Lymphopenia:

Lymphopenia (889 drugs)

Browse all the conditions that are associated with Lymphopenia:

Lymphopenia (1,078 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sulfamethoxazole; trimethoprim (the active ingredients of Cotrim) and Cotrim (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.