Cotrim and Noises or buzzing in the ears - a phase IV clinical study of FDA data

Summary:

Noises or buzzing in the ears is reported as a side effect among people who take Cotrim (sulfamethoxazole; trimethoprim), especially for people who are male, 60+ old, also take Allopurinol, and have Mood swings.

The phase IV clinical study analyzes which people have Noises or buzzing in the ears when taking Cotrim. It is created by eHealthMe based on reports of 8,881 people who have side effects when taking Cotrim from the FDA, and is updated regularly.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

What is Noises or buzzing in the ears?

Noises or buzzing in the ears is found to be associated with 2,382 drugs and 3,192 conditions by eHealthMe. Check the latest studies of Noises or buzzing in the ears.

On May, 11, 2026

8,881 people reported to have side effects when taking Cotrim.
Among them, 22 people (0.25%) have Noises or buzzing in the ears.

Could Cotrim cause Noises or buzzing in the ears?

Among these 22 people:

What is the gender of people who have Noises or buzzing in the ears when taking Cotrim? *

female: 4.76 %
male: 95.24 %

What is the age of people who have Noises or buzzing in the ears when taking Cotrim? *

What are other drugs people take besides Cotrim? *

What are other side effects people have besides Noises or buzzing in the ears? *

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 15 people, 68.18%
Thrombocytopenia (decrease of platelets in blood): 14 people, 63.64%
Diarrhea: 14 people, 63.64%
Dry Skin: 14 people, 63.64%
Fatigue (feeling of tiredness): 13 people, 59.09%
Dizziness: 13 people, 59.09%
Dyspnea (difficult or laboured breathing): 13 people, 59.09%
Renal Impairment (severely reduced kidney function): 13 people, 59.09%
Depression: 13 people, 59.09%
High Blood Cholesterol: 13 people, 59.09%

What are the existing conditions these people have? *

Seborrhoeic Dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp): 12 people, 54.55%
Joint Pain: 12 people, 54.55%
Diarrhea: 12 people, 54.55%
Fluid Retention (an abnormal accumulation of fluid in the blood): 12 people, 54.55%
High Blood Cholesterol: 12 people, 54.55%
High Blood Pressure: 12 people, 54.55%
Multiple Myeloma (cancer of the plasma cells): 12 people, 54.55%
Mood Swings (an extreme or rapid change in mood): 12 people, 54.55%
Seasonal Allergy (allergic condition due to certain season): 6 people, 27.27%
Blood Triglycerides Decreased: 6 people, 27.27%

* Approximation only. Some reports may have incomplete information.

Do you take Cotrim and have Noises or buzzing in the ears?

- Check whether Noises or buzzing in the ears is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cotrim:

Cotrim (8,890 reports)

Noises or buzzing in the ears treatments and more:

Noises or buzzing in the ears (58,551 reports)

How severe was Noises or buzzing in the ears and when was it recovered:

Noises or buzzing in the ears in Cotrim

Expand to all the drugs that have ingredients of sulfamethoxazole; trimethoprim:

Noises or buzzing in the ears and drugs with ingredients of sulfamethoxazole; trimethoprim (689 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cotrim:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Noises or buzzing in the ears:

Noises or buzzing in the ears (2,382 drugs)

Browse all the conditions that are associated with Noises or buzzing in the ears:

Noises or buzzing in the ears (3,192 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sulfamethoxazole; trimethoprim (the active ingredients of Cotrim) and Cotrim (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.