Cotrim and Osteoarthritis - a phase IV clinical study of FDA data

Summary:

Osteoarthritis is reported as a side effect among people who take Cotrim (sulfamethoxazole; trimethoprim), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Levaquin, and have High blood pressure.

The phase IV clinical study analyzes which people have Osteoarthritis when taking Cotrim. It is created by eHealthMe based on reports of 8,881 people who have side effects when taking Cotrim from the FDA, and is updated regularly.

What is Cotrim?

Cotrim has active ingredients of sulfamethoxazole; trimethoprim. eHealthMe is studying from 8,890 Cotrim users. Check the latest studies of Cotrim.

What is Osteoarthritis?

Osteoarthritis (a joint disease caused by cartilage loss in a joint) is found to be associated with 1,880 drugs and 2,647 conditions by eHealthMe. Check the latest studies of Osteoarthritis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

8,881 people reported to have side effects when taking Cotrim.
Among them, 27 people (0.3%) have Osteoarthritis.

Among these 27 people:

How long have people been on Cotrim when they have Osteoarthritis? *

What is the gender of people who have Osteoarthritis when taking Cotrim? *

female: 20 %
male: 80 %

What is the age of people who have Osteoarthritis when taking Cotrim? *

What are other drugs people take besides Cotrim? *

What are other side effects people have besides Osteoarthritis? *

Stress And Anxiety: 11 people, 40.74%
Upper Respiratory Tract Infection: 11 people, 40.74%
Joint Pain: 11 people, 40.74%
Back Pain: 11 people, 40.74%
Weight Increased: 10 people, 37.04%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 10 people, 37.04%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 10 people, 37.04%
Pain: 10 people, 37.04%
Cellulitis (infection under the skin): 10 people, 37.04%
Hyperlipidaemia (presence of excess lipids in the blood): 10 people, 37.04%

What are the existing conditions these people have? *

High Blood Pressure: 5 people, 18.52%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 3 people, 11.11%
Sleep Disorder: 3 people, 11.11%
Sinusitis (inflammation of sinus): 3 people, 11.11%
Rickets (softening of bones): 3 people, 11.11%
Upper Respiratory Tract Infection: 3 people, 11.11%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 3 people, 11.11%
Hiv Infection: 3 people, 11.11%
Dizziness: 3 people, 11.11%
Infection: 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

Do you take Cotrim and have Osteoarthritis?

- Check whether Osteoarthritis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cotrim:

Cotrim (8,890 reports)

Osteoarthritis treatments and more:

Osteoarthritis (95,655 reports)

How severe was Osteoarthritis and when was it recovered:

Osteoarthritis in Cotrim

Expand to all the drugs that have ingredients of sulfamethoxazole; trimethoprim:

Osteoarthritis and drugs with ingredients of sulfamethoxazole; trimethoprim (1,190 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cotrim:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteoarthritis:

Osteoarthritis (1,880 drugs)

Browse all the conditions that are associated with Osteoarthritis:

Osteoarthritis (2,647 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on sulfamethoxazole; trimethoprim (the active ingredients of Cotrim) and Cotrim (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.