Creon and C. diff - a phase IV clinical study of FDA data

Summary:

C. diff is reported as a side effect among people who take Creon (pancrelipase (amylase;lipase;protease)), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Pantoprazole, and have High blood pressure.

The phase IV clinical study analyzes which people have C. diff when taking Creon. It is created by eHealthMe based on reports of 29,220 people who have side effects when taking Creon from the FDA, and is updated regularly.

What is Creon?

Creon has active ingredients of pancrelipase (amylase;lipase;protease). It is often used in pancreatitis. eHealthMe is studying from 29,488 Creon users. Check the latest studies of Creon.

What is C. diff?

C. diff is found to be associated with 1,621 drugs and 1,769 conditions by eHealthMe. Check the latest studies of C. diff.

On Jan, 03, 2026

29,220 people reported to have side effects when taking Creon.
Among them, 40 people (0.14%) have C. diff.

Among these 40 people:

How long have people been on Creon when they have C. diff? *

What is the gender of people who have C. diff when taking Creon? *

female: 62.86 %
male: 37.14 %

What is the age of people who have C. diff when taking Creon? *

What are other drugs people take besides Creon? *

Pantoprazole: 13 people, 32.50%
Sulfamethoxazole And Trimethoprim: 8 people, 20.00%
Omeprazole: 8 people, 20.00%
Ondansetron: 7 people, 17.50%
Zofran: 6 people, 15.00%
Pulmozyme: 6 people, 15.00%
Lomotil: 6 people, 15.00%
Vancomycin: 6 people, 15.00%
Abraxane: 5 people, 12.50%
Sodium Chloride: 5 people, 12.50%

What are other side effects people have besides C. diff? *

Fever: 9 people, 22.50%
Diarrhea: 8 people, 20.00%
Urinary Tract Infection: 7 people, 17.50%
Pneumonia: 7 people, 17.50%
Abdominal Distension: 6 people, 15.00%
Abdominal Pain: 6 people, 15.00%
Weakness: 5 people, 12.50%
Small Intestinal Obstruction (blockage in small intestine): 5 people, 12.50%
Pseudomonas Infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa): 5 people, 12.50%
Enterococcal Infection: 4 people, 10.00%

What are the existing conditions these people have? *

High Blood Pressure: 10 people, 25.00%
Nausea (feeling of having an urge to vomit): 7 people, 17.50%
Diarrhea: 7 people, 17.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 15.00%
Cystic Fibrosis (disease of the secretary glands): 5 people, 12.50%
Depression: 5 people, 12.50%
Gastritis (inflammation of stomach): 4 people, 10.00%
Swelling: 4 people, 10.00%
Sepsis (a severe blood infection that can lead to organ failure and death): 4 people, 10.00%
Pancreatic Carcinoma (pancreatic cancer): 4 people, 10.00%

* Approximation only. Some reports may have incomplete information.

Do you take Creon and have C. diff?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Creon:

Creon (29,488 reports)

C. diff treatments and more:

C. diff (13,844 reports)

How severe was C. diff and when was it recovered:

C. diff in Creon

Expand to all the drugs that have ingredients of pancrelipase (amylase;lipase;protease):

C. diff and drugs with ingredients of pancrelipase (amylase;lipase;protease) (55 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Creon:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with C. diff:

C. diff (1,621 drugs)

Browse all the conditions that are associated with C. diff:

C. diff (1,769 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pancrelipase (amylase;lipase;protease) (the active ingredients of Creon) and Creon (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.