Creon and Disease recurrence - a phase IV clinical study of FDA data

Summary:

Disease recurrence is reported as a side effect among people who take Creon (pancrelipase (amylase;lipase;protease)), especially for people who are male, 60+ old, have been taking the drug for 2 - 5 years also take Paxlovid, and have Neuroendocrine tumor.

The phase IV clinical study analyzes which people have Disease recurrence when taking Creon. It is created by eHealthMe based on reports of 29,220 people who have side effects when taking Creon from the FDA, and is updated regularly.

What is Creon?

Creon has active ingredients of pancrelipase (amylase;lipase;protease). It is often used in pancreatitis. eHealthMe is studying from 29,489 Creon users. Check the latest studies of Creon.

What is Disease recurrence?

Disease recurrence is found to be associated with 1,244 drugs and 1,552 conditions by eHealthMe. Check the latest studies of Disease recurrence.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

29,220 people reported to have side effects when taking Creon.
Among them, 22 people (0.08%) have Disease recurrence.

Among these 22 people:

How long have people been on Creon when they have Disease recurrence? *

What is the gender of people who have Disease recurrence when taking Creon? *

female: 45.45 %
male: 54.55 %

What is the age of people who have Disease recurrence when taking Creon? *

What are other drugs people take besides Creon? *

Aspirin: 7 people, 31.82%
Paxlovid: 7 people, 31.82%
Sandostatin: 6 people, 27.27%
Levofloxacin: 5 people, 22.73%
Nitroglycerin: 5 people, 22.73%
Fluoxetine: 5 people, 22.73%
Indapamide: 5 people, 22.73%
Metformin Hydrochloride: 2 people, 9.09%
Lexapro: 2 people, 9.09%
Omeprazole: 2 people, 9.09%

What are other side effects people have besides Disease recurrence? *

Fatigue (feeling of tiredness): 7 people, 31.82%
Malaise (a feeling of general discomfort or uneasiness): 7 people, 31.82%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 6 people, 27.27%
Bone Pain: 6 people, 27.27%
Depressed Mood: 5 people, 22.73%
Feeding Disorder (when children refuse to eat certain food groups): 5 people, 22.73%
Nausea And Vomiting: 5 people, 22.73%
High Blood Pressure: 5 people, 22.73%
Drug Hypersensitivity: 5 people, 22.73%
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough): 5 people, 22.73%

What are the existing conditions these people have? *

Neuroendocrine Tumor: 5 people, 22.73%
Pain: 2 people, 9.09%
Pancreatic Disorder: 2 people, 9.09%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 1 person, 4.55%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 4.55%
Aortitis (inflammation of the aortic wall): 1 person, 4.55%
Bone Pain: 1 person, 4.55%
Cardiac Disorder: 1 person, 4.55%
Clostridium Difficile Colitis (inflammation of colon by clostridium difficile bacteria infection): 1 person, 4.55%
Constipation: 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Creon and have Disease recurrence?

- Check whether Disease recurrence is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Creon:

Creon (29,489 reports)

Disease recurrence treatments and more:

Disease recurrence (47,276 reports)

How severe was Disease recurrence and when was it recovered:

Disease recurrence in Creon

Expand to all the drugs that have ingredients of pancrelipase (amylase;lipase;protease):

Disease recurrence and drugs with ingredients of pancrelipase (amylase;lipase;protease)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Creon:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Disease recurrence:

Disease recurrence (1,244 drugs)

Browse all the conditions that are associated with Disease recurrence:

Disease recurrence (1,552 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pancrelipase (amylase;lipase;protease) (the active ingredients of Creon) and Creon (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.