Creon and Hyperkeratosis - a phase IV clinical study of FDA data

Summary:

Hyperkeratosis is reported as a side effect among people who take Creon (pancrelipase (amylase;lipase;protease)), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Pantoprazole, and have Pain.

The phase IV clinical study analyzes which people have Hyperkeratosis when taking Creon. It is created by eHealthMe based on reports of 29,220 people who have side effects when taking Creon from the FDA, and is updated regularly.

What is Creon?

Creon has active ingredients of pancrelipase (amylase;lipase;protease). It is often used in pancreatitis. eHealthMe is studying from 29,489 Creon users. Check the latest studies of Creon.

What is Hyperkeratosis?

Hyperkeratosis (thickening of the outer layer of the skin) is found to be associated with 778 drugs and 774 conditions by eHealthMe. Check the latest studies of Hyperkeratosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

29,220 people reported to have side effects when taking Creon.
Among them, 13 people (0.04%) have Hyperkeratosis.

Among these 13 people:

How long have people been on Creon when they have Hyperkeratosis? *

What is the gender of people who have Hyperkeratosis when taking Creon? *

female: 66.67 %
male: 33.33 %

What is the age of people who have Hyperkeratosis when taking Creon? *

What are other drugs people take besides Creon? *

What are other side effects people have besides Hyperkeratosis? *

Fatigue (feeling of tiredness): 6 people, 46.15%
Stress And Anxiety: 5 people, 38.46%
Pain: 5 people, 38.46%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 5 people, 38.46%
Foot Deformity (functional disability of foot): 4 people, 30.77%
Pain In Extremity: 4 people, 30.77%
Abdominal Pain: 3 people, 23.08%
Poor Quality Sleep: 3 people, 23.08%
Fall: 3 people, 23.08%
Diarrhea: 3 people, 23.08%

What are the existing conditions these people have? *

Type 2 Diabetes: 2 people, 15.38%
Lipids Abnormal: 2 people, 15.38%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 15.38%
Gastrointestinal Stromal Tumor: 2 people, 15.38%
Tuberculosis (a bacterial infection by mycobacterium tuberculosis): 2 people, 15.38%
Asthma: 2 people, 15.38%
Neuropathy Peripheral (surface nerve damage): 2 people, 15.38%
Pain: 2 people, 15.38%
Metastases To Adrenals (cancer spreads to adrenal gland of kidney): 1 person, 7.69%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Creon and have Hyperkeratosis?

- Check whether Hyperkeratosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Creon:

Creon (29,489 reports)

Hyperkeratosis treatments and more:

Hyperkeratosis (8,056 reports)

How severe was Hyperkeratosis and when was it recovered:

Hyperkeratosis in Creon

Expand to all the drugs that have ingredients of pancrelipase (amylase;lipase;protease):

Hyperkeratosis and drugs with ingredients of pancrelipase (amylase;lipase;protease)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Creon:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperkeratosis:

Hyperkeratosis (778 drugs)

Browse all the conditions that are associated with Hyperkeratosis:

Hyperkeratosis (774 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pancrelipase (amylase;lipase;protease) (the active ingredients of Creon) and Creon (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.