Creon and Oedema - a phase IV clinical study of FDA data

Summary:

Oedema is reported as a side effect among people who take Creon (pancrelipase (amylase;lipase;protease)), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Afinitor, and have Neuroendocrine tumor.

The phase IV clinical study analyzes which people have Oedema when taking Creon. It is created by eHealthMe based on reports of 29,220 people who have side effects when taking Creon from the FDA, and is updated regularly.

What is Creon?

Creon has active ingredients of pancrelipase (amylase;lipase;protease). It is often used in pancreatitis. eHealthMe is studying from 29,486 Creon users. Check the latest studies of Creon.

What is Oedema?

Oedema (fluid collection in tissue) is found to be associated with 2,276 drugs and 2,303 conditions by eHealthMe. Check the latest studies of Oedema.

On Sep, 07, 2025

29,220 people reported to have side effects when taking Creon.
Among them, 116 people (0.4%) have Oedema.

Among these 116 people:

How long have people been on Creon when they have Oedema? *

What is the gender of people who have Oedema when taking Creon? *

female: 52.38 %
male: 47.62 %

What is the age of people who have Oedema when taking Creon? *

What are other drugs people take besides Creon? *

What are other side effects people have besides Oedema? *

Rashes (redness): 32 people, 27.59%
Diarrhea: 24 people, 20.69%
Urticaria (rash of round, red welts on the skin that itch intensely): 22 people, 18.97%
Weakness: 21 people, 18.10%
Dyspnea (difficult or laboured breathing): 21 people, 18.10%
Mucosal Inflammation (infection of mucous membrane): 19 people, 16.38%
Thrombocytopenia (decrease of platelets in blood): 19 people, 16.38%
Fatigue (feeling of tiredness): 16 people, 13.79%
Hepatocellular Injury (liver injury): 15 people, 12.93%
Insomnia (sleeplessness): 14 people, 12.07%

What are the existing conditions these people have? *

Neuroendocrine Tumor: 16 people, 13.79%
Pancreatic Neuroendocrine Tumor: 15 people, 12.93%
High Blood Pressure: 14 people, 12.07%
Diarrhea: 11 people, 9.48%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 8.62%
Nausea (feeling of having an urge to vomit): 10 people, 8.62%
Pancreatic Carcinoma (pancreatic cancer): 9 people, 7.76%
Steatorrhea: 8 people, 6.90%
Pain: 7 people, 6.03%
Cystic Fibrosis (disease of the secretary glands): 7 people, 6.03%

* Approximation only. Some reports may have incomplete information.

Do you take Creon and have Oedema?

- Check whether Oedema is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Creon:

Creon (29,486 reports)

Oedema treatments and more:

Oedema (78,747 reports)

How severe was Oedema and when was it recovered:

Oedema in Creon

Expand to all the drugs that have ingredients of pancrelipase (amylase;lipase;protease):

Oedema and drugs with ingredients of pancrelipase (amylase;lipase;protease)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Creon side effects:

Browse all side effects of Creon:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Oedema:

Browse all the drugs that are associated with Oedema:

Oedema (2,276 drugs)

Common conditions associated with Oedema:

Primary pulmonary hypertension: 6,129 reports
Ra: 3,591 reports
Hypertension: 3,430 reports
Blood pressure increased: 3,383 reports
Pulmonary hypertension: 2,340 reports
Pain: 1,958 reports
Alternative medicine - pain relief: 1,909 reports
Plasma cell myeloma: 1,569 reports
Diabetes mellitus: 1,473 reports
Diabetes: 1,437 reports

Browse all the conditions that are associated with Oedema:

Oedema (2,303 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on pancrelipase (amylase;lipase;protease) (the active ingredients of Creon) and Creon (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.