Crestor and Gastrointestinal perforation - a phase IV clinical study of FDA data

Summary:

Gastrointestinal perforation is reported as a side effect among people who take Crestor (rosuvastatin calcium), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Pantoprazole, and have High blood pressure.

The phase IV clinical study analyzes which people have Gastrointestinal perforation when taking Crestor. It is created by eHealthMe based on reports of 143,349 people who have side effects when taking Crestor from the FDA, and is updated regularly.

What is Crestor?

Crestor has active ingredients of rosuvastatin calcium. It is often used in high blood cholesterol. eHealthMe is studying from 149,761 Crestor users. Check the latest studies of Crestor.

What is Gastrointestinal perforation?

Gastrointestinal perforation (hole in the digestive tract) is found to be associated with 934 drugs and 1,394 conditions by eHealthMe. Check the latest studies of Gastrointestinal perforation.

On Jul, 09, 2026

143,349 people reported to have side effects when taking Crestor.
Among them, 88 people (0.06%) have Gastrointestinal perforation.

Could Crestor cause Gastrointestinal perforation?

Among these 88 people:

How long have people been on Crestor when they have Gastrointestinal perforation? *

What is the gender of people who have Gastrointestinal perforation when taking Crestor? *

female: 44.05 %
male: 55.95 %

What is the age of people who have Gastrointestinal perforation when taking Crestor? *

What are other drugs people take besides Crestor? *

What are other side effects people have besides Gastrointestinal perforation? *

Septic Shock (shock due to blood infection): 14 people, 15.91%
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs): 13 people, 14.77%
Colitis (inflammation of colon): 11 people, 12.50%
Anaemia (lack of blood): 10 people, 11.36%
Diarrhea: 9 people, 10.23%
Intestinal Obstruction: 8 people, 9.09%
Headache (pain in head): 8 people, 9.09%
Drug Ineffective: 7 people, 7.95%
Pulmonary Embolism (blockage of the main artery of the lung): 7 people, 7.95%
Disseminated Intravascular Coagulation (systemic activation of blood coagulation): 7 people, 7.95%

What are the existing conditions these people have? *

High Blood Pressure: 17 people, 19.32%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 11 people, 12.50%
Diabetes: 9 people, 10.23%
Malignant Melanoma (skin cancer rises from melancytes): 9 people, 10.23%
Dyslipidaemia (abnormal amount of lipids): 8 people, 9.09%
Anaemia (lack of blood): 7 people, 7.95%
Gastric Ulcer (stomach ulcer): 7 people, 7.95%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 6.82%
Hyperkalemia (damage to or disease of the kidney): 5 people, 5.68%
Pain: 5 people, 5.68%

* Approximation only. Some reports may have incomplete information.

Do you take Crestor and have Gastrointestinal perforation?

- Check whether Gastrointestinal perforation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Crestor:

Crestor (149,761 reports)

Browse all side effects of Crestor:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gastrointestinal perforation:

Gastrointestinal perforation (934 drugs)

Browse all the conditions that are associated with Gastrointestinal perforation:

Gastrointestinal perforation (1,394 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on rosuvastatin calcium (the active ingredients of Crestor) and Crestor (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.