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Cyclophosphamide and Cell-mediated immune deficiency - a phase IV clinical study of FDA data

Summary:

Cell-mediated immune deficiency is reported as a side effect among people who take Cyclophosphamide (cyclophosphamide), especially for people who are male, 60+ old, have been taking the drug for 1 - 2 years also take Prednisone, and have Chronic lymphocytic leukaemia.

The phase IV clinical study analyzes which people have Cell-mediated immune deficiency when taking Cyclophosphamide. It is created by eHealthMe based on reports of 185,094 people who have side effects when taking Cyclophosphamide from the FDA, and is updated regularly.

What is Cyclophosphamide?

Cyclophosphamide has active ingredients of cyclophosphamide. It is often used in multiple myeloma. eHealthMe is studying from 185,240 Cyclophosphamide users. Check the latest studies of Cyclophosphamide.

What is Cell-mediated immune deficiency?

Cell-mediated immune deficiency (loss of defence mechanism of cell) is found to be associated with 16 drugs and 90 conditions by eHealthMe. Check the latest studies of Cell-mediated immune deficiency.

On Aug, 02, 2026

185,094 people reported to have side effects when taking Cyclophosphamide.
Among them, 11 people (0.01%) have Cell-mediated immune deficiency.

Could Cyclophosphamide cause Cell-mediated immune deficiency?

Among these 11 people:

How long have people been on Cyclophosphamide when they have Cell-mediated immune deficiency? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 100 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Cell-mediated immune deficiency when taking Cyclophosphamide? *

  • female: 45.45 %
  • male: 54.55 %

What is the age of people who have Cell-mediated immune deficiency when taking Cyclophosphamide? *

  • 0-1: 9.09 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 18.18 %
  • 50-59: 0.0 %
  • 60+: 72.73 %

What are other drugs people take besides Cyclophosphamide? *

  1. Prednisone: 7 people, 63.64%
  2. Vincristine Sulfate: 2 people, 18.18%
  3. Bendamustine: 2 people, 18.18%
  4. Prednisolone: 1 person, 9.09%
  5. Methotrexate: 1 person, 9.09%
  6. Etoposide: 1 person, 9.09%
  7. Doxorubicin Hydrochloride: 1 person, 9.09%
  8. Dexamethasone: 1 person, 9.09%
  9. Cytarabine: 1 person, 9.09%
  10. Cyclosporine: 1 person, 9.09%

What are other side effects people have besides Cell-mediated immune deficiency? *

  1. Acute Kidney Failure: 3 people, 27.27%
  2. Progressive Multifocal Leukoencephalopathy (rapidly progressive neuromuscular disease caused by opportunistic infection of brain cells): 3 people, 27.27%
  3. Humoral Immune Defect (impairment of humoral immunity): 3 people, 27.27%
  4. Encephalitis (inflammation of the brain): 2 people, 18.18%
  5. Fever: 2 people, 18.18%
  6. Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 2 people, 18.18%
  7. Blood Osmolarity Increased: 2 people, 18.18%
  8. Blood Lactate Dehydrogenase Increased: 2 people, 18.18%
  9. Pneumonia: 2 people, 18.18%
  10. Blood Albumin Decreased: 2 people, 18.18%

What are the existing conditions these people have? *

  1. Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 3 people, 27.27%
  2. Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 2 people, 18.18%
  3. Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 2 people, 18.18%
  4. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 18.18%
  5. Burkitt Lymphoma (cancer of the lymphatic system): 2 people, 18.18%
  6. Waldenstrom's Macroglobulinaemia (cancer affects small lymphocytes (white blood cells)): 1 person, 9.09%
  7. Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 1 person, 9.09%
  8. Nephrotic Syndrome (kidney disease with proteinuria, hypoalbuminemia, and oedema): 1 person, 9.09%
  9. Malignant Lymphoid Neoplasm (malignant growth or tumour caused by abnormal and uncontrolled cell division in lymph node): 1 person, 9.09%
  10. Hodgkin's Lymphoma (cancer originating from white blood cells): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Cyclophosphamide and have Cell-mediated immune deficiency?

- Check whether Cell-mediated immune deficiency is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cyclophosphamide:

Cell-mediated immune deficiency treatments and more:

How severe was Cell-mediated immune deficiency and when was it recovered:

Expand to all the drugs that have ingredients of cyclophosphamide:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cyclophosphamide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cell-mediated immune deficiency:

Browse all the conditions that are associated with Cell-mediated immune deficiency:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on cyclophosphamide (the active ingredients of Cyclophosphamide) and Cyclophosphamide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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