Cyclophosphamide and Hypertensive emergency - a phase IV clinical study of FDA data

Summary:

Hypertensive emergency is reported as a side effect among people who take Cyclophosphamide (cyclophosphamide), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Amlodipine, and have High blood pressure.

The phase IV clinical study analyzes which people have Hypertensive emergency when taking Cyclophosphamide. It is created by eHealthMe based on reports of 185,094 people who have side effects when taking Cyclophosphamide from the FDA, and is updated regularly.

What is Cyclophosphamide?

Cyclophosphamide has active ingredients of cyclophosphamide. It is often used in multiple myeloma. eHealthMe is studying from 185,240 Cyclophosphamide users. Check the latest studies of Cyclophosphamide.

What is Hypertensive emergency?

Hypertensive emergency is found to be associated with 133 drugs and 258 conditions by eHealthMe. Check the latest studies of Hypertensive emergency.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

185,094 people reported to have side effects when taking Cyclophosphamide.
Among them, 21 people (0.01%) have Hypertensive emergency.

Could Cyclophosphamide cause Hypertensive emergency?

Among these 21 people:

How long have people been on Cyclophosphamide when they have Hypertensive emergency? *

What is the gender of people who have Hypertensive emergency when taking Cyclophosphamide? *

female: 63.16 %
male: 36.84 %

What is the age of people who have Hypertensive emergency when taking Cyclophosphamide? *

What are other drugs people take besides Cyclophosphamide? *

What are other side effects people have besides Hypertensive emergency? *

High Blood Pressure: 6 people, 28.57%
Fever: 6 people, 28.57%
Pulmonary Oedema (fluid accumulation in the lungs): 5 people, 23.81%
Posterior Reversible Encephalopathy Syndrome (posterior reversible encephalopathy syndrome (pres), also known as reversible posterior leukoencephalopathy syndrome (rpls), is a syndrome characterized by headache, confusion, seizures and visual loss): 5 people, 23.81%
Headache (pain in head): 4 people, 19.05%
Hyperkalemia (damage to or disease of the kidney): 4 people, 19.05%
Anaphylactoid Reaction (type of anaphylaxis that does not involve an allergic reaction but is due to direct mast cell degranulation): 4 people, 19.05%
Infection: 3 people, 14.29%
Stress And Anxiety: 3 people, 14.29%
Cytokine Release Syndrome (immediate complication occurring with the use of anti-t cell antibody infusions): 3 people, 14.29%

What are the existing conditions these people have? *

High Blood Pressure: 5 people, 23.81%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 3 people, 14.29%
Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 3 people, 14.29%
Adrenocortical Insufficiency Acute (suddenly adrenal glands do not produce adequate amounts of steroid hormones): 3 people, 14.29%
Stomatitis (inflammation of mucous membrane of mouth): 2 people, 9.52%
Renal Vein Thrombosis (blood clot in renal vein): 2 people, 9.52%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 2 people, 9.52%
Diffuse Large B-Cell Lymphoma Recurrent (recurrent cancer of b cells, a type of white blood cell): 2 people, 9.52%
Bladder Disorder: 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Cyclophosphamide and have Hypertensive emergency?

- Check whether Hypertensive emergency is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cyclophosphamide:

Cyclophosphamide (185,240 reports)

Browse all side effects of Cyclophosphamide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypertensive emergency:

Hypertensive emergency (133 drugs)

Browse all the conditions that are associated with Hypertensive emergency:

Hypertensive emergency (258 conditions)

Related publications that referenced our studies

Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .
Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .

How the study uses the data?

The study uses data from the FDA. It is based on cyclophosphamide (the active ingredients of Cyclophosphamide) and Cyclophosphamide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.