Listerine and Application site exfoliation - a phase IV clinical study of FDA data

Summary:

Application site exfoliation is reported as a side effect among people who take Listerine (menthol, thymol, methyl salicylate, eucalyptol), especially for people who are female, 20-29 old, have been taking the drug for 1 - 6 months also take Hygroton, and have Diabetes.

The phase IV clinical study analyzes which people have Application site exfoliation when taking Listerine. It is created by eHealthMe based on reports of 1,150 people who have side effects when taking Listerine from the FDA, and is updated regularly.

What is Listerine?

Listerine has active ingredients of menthol, thymol, methyl salicylate, eucalyptol. eHealthMe is studying from 1,164 Listerine users. Check the latest studies of Listerine.

What is Application site exfoliation?

Application site exfoliation (application site removal of the oldest dead skin cells on the skin's outermost surface) is found to be associated with 174 drugs and 353 conditions by eHealthMe. Check the latest studies of Application site exfoliation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

1,150 people reported to have side effects when taking Listerine.
Among them, 16 people (1.39%) have Application site exfoliation.

Could Listerine cause Application site exfoliation?

Among these 16 people:

How long have people been on Listerine when they have Application site exfoliation? *

What is the gender of people who have Application site exfoliation when taking Listerine? *

female: 56.25 %
male: 43.75 %

What is the age of people who have Application site exfoliation when taking Listerine? *

What are other drugs people take besides Listerine? *

Omeprazole: 2 people, 12.50%
Metoprolol Succinate: 2 people, 12.50%
Metformin Hydrochloride: 2 people, 12.50%
Hygroton: 2 people, 12.50%
Norvasc: 1 person, 6.25%
Humira: 1 person, 6.25%

What are other side effects people have besides Application site exfoliation? *

Ageusia (loss of taste functions of the tongue): 12 people, 75.00%
Wound: 10 people, 62.50%
Gingival Erythema (redness of gums): 10 people, 62.50%
Application Site Pain: 3 people, 18.75%
Application Site Burn: 2 people, 12.50%
Urinary Tract Infection: 1 person, 6.25%
Premature Rupture Of Membranes: 1 person, 6.25%
Oral Disorder (mouth disease): 1 person, 6.25%
Eating Disorder: 1 person, 6.25%
Discomfort: 1 person, 6.25%

What are the existing conditions these people have? *

Gastric Disorder (disease of stomach): 2 people, 12.50%
Diabetes: 2 people, 12.50%
High Blood Pressure: 1 person, 6.25%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Listerine and have Application site exfoliation?

- Check whether Application site exfoliation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Listerine:

Listerine (1,164 reports)

Application site exfoliation treatments and more:

Application site exfoliation (4,028 reports)

How severe was Application site exfoliation and when was it recovered:

Application site exfoliation in Listerine

Expand to all the drugs that have ingredients of menthol, thymol, methyl salicylate, eucalyptol:

Application site exfoliation and drugs with ingredients of menthol, thymol, methyl salicylate, eucalyptol (16 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Listerine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Application site exfoliation:

Application site exfoliation (174 drugs)

Browse all the conditions that are associated with Application site exfoliation:

Application site exfoliation (353 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on menthol, thymol, methyl salicylate, eucalyptol (the active ingredients of Listerine) and Listerine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.