Cyclophosphamide and Tibia fracture - a phase IV clinical study of FDA data

Summary:

Tibia fracture is reported as a side effect among people who take Cyclophosphamide (cyclophosphamide), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Methotrexate, and have Breast cancer.

The phase IV clinical study analyzes which people have Tibia fracture when taking Cyclophosphamide. It is created by eHealthMe based on reports of 185,094 people who have side effects when taking Cyclophosphamide from the FDA, and is updated regularly.

What is Cyclophosphamide?

Cyclophosphamide has active ingredients of cyclophosphamide. It is often used in multiple myeloma. eHealthMe is studying from 185,240 Cyclophosphamide users. Check the latest studies of Cyclophosphamide.

What is Tibia fracture?

Tibia fracture (fracture of lower leg bone) is found to be associated with 643 drugs and 670 conditions by eHealthMe. Check the latest studies of Tibia fracture.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

185,094 people reported to have side effects when taking Cyclophosphamide.
Among them, 20 people (0.01%) have Tibia fracture.

$Could Cyclophosphamide cause Tibia fracture?$

Among these 20 people:

How long have people been on Cyclophosphamide when they have Tibia fracture? *

What is the gender of people who have Tibia fracture when taking Cyclophosphamide? *

female: 94.44 %
male: 5.56 %

What is the age of people who have Tibia fracture when taking Cyclophosphamide? *

What are other drugs people take besides Cyclophosphamide? *

What are other side effects people have besides Tibia fracture? *

Fatigue (feeling of tiredness): 8 people, 40.00%
Fall: 7 people, 35.00%
Herpes Zoster: 6 people, 30.00%
Fibula Fracture: 6 people, 30.00%
Pain In Extremity: 5 people, 25.00%
Urinary Tract Infection: 5 people, 25.00%
Humerus Fracture (injury to the upper arm bone): 5 people, 25.00%
Dyspnea (difficult or laboured breathing): 5 people, 25.00%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 5 people, 25.00%
Gait Disturbance: 5 people, 25.00%

What are the existing conditions these people have? *

Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 3 people, 15.00%
High Blood Pressure: 3 people, 15.00%
Breast Cancer: 3 people, 15.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 10.00%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 10.00%
Osteoporosis (bones weak and more likely to break): 2 people, 10.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 10.00%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 10.00%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 10.00%
Breast Cancer Metastatic: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Cyclophosphamide and have Tibia fracture?

- Check whether Tibia fracture is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cyclophosphamide:

Cyclophosphamide (185,240 reports)

Tibia fracture treatments and more:

Tibia fracture (6,376 reports)

Browse all side effects of Cyclophosphamide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Tibia fracture:

Tibia fracture (643 drugs)

Browse all the conditions that are associated with Tibia fracture:

Tibia fracture (670 conditions)

Related publications that referenced our studies

Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .
Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .

How the study uses the data?

The study uses data from the FDA. It is based on cyclophosphamide (the active ingredients of Cyclophosphamide) and Cyclophosphamide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.