Cyclophosphamide and Ulcerative keratitis - a phase IV clinical study of FDA data

Summary:

Ulcerative keratitis is reported as a side effect among people who take Cyclophosphamide (cyclophosphamide), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Cytarabine, and have Burkitt's lymphoma.

The phase IV clinical study analyzes which people have Ulcerative keratitis when taking Cyclophosphamide. It is created by eHealthMe based on reports of 185,094 people who have side effects when taking Cyclophosphamide from the FDA, and is updated regularly.

What is Cyclophosphamide?

Cyclophosphamide has active ingredients of cyclophosphamide. It is often used in multiple myeloma. eHealthMe is studying from 185,240 Cyclophosphamide users. Check the latest studies of Cyclophosphamide.

What is Ulcerative keratitis?

Ulcerative keratitis (ulcerative inflammation of the cornea) is found to be associated with 295 drugs and 743 conditions by eHealthMe. Check the latest studies of Ulcerative keratitis.

On Jul, 11, 2026

185,094 people reported to have side effects when taking Cyclophosphamide.
Among them, 23 people (0.01%) have Ulcerative keratitis.

Could Cyclophosphamide cause Ulcerative keratitis?

Among these 23 people:

How long have people been on Cyclophosphamide when they have Ulcerative keratitis? *

What is the gender of people who have Ulcerative keratitis when taking Cyclophosphamide? *

female: 21.05 %
male: 78.95 %

What is the age of people who have Ulcerative keratitis when taking Cyclophosphamide? *

What are other drugs people take besides Cyclophosphamide? *

Cytarabine: 6 people, 26.09%
Doxorubicin Hydrochloride: 4 people, 17.39%
Methotrexate Sodium: 4 people, 17.39%
Vincristine Sulfate: 4 people, 17.39%
Eliquis: 3 people, 13.04%
Azathioprine: 3 people, 13.04%
Clopidogrel: 3 people, 13.04%
Lenalidomide: 3 people, 13.04%
Methotrexate: 2 people, 8.70%
Prednisone: 2 people, 8.70%

What are other side effects people have besides Ulcerative keratitis? *

Haemorrhage (bleeding): 6 people, 26.09%
Ileus Paralytic (obstruction of the intestine due to paralysis of the intestinal muscles): 6 people, 26.09%
Dermatitis Bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid): 6 people, 26.09%
Vision Blurred: 4 people, 17.39%
Rashes (redness): 4 people, 17.39%
General Physical Health Deterioration (weak health status): 3 people, 13.04%
Leukopenia (less number of white blood cells in blood): 3 people, 13.04%
Chills (felling of cold): 3 people, 13.04%
Neuroendocrine Tumor: 3 people, 13.04%
Cholecystitis (infection of gallbladder): 3 people, 13.04%

What are the existing conditions these people have? *

Burkitt's Lymphoma (cancer of the lymphatic system): 6 people, 26.09%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 4 people, 17.39%
Burkitt Lymphoma (cancer of the lymphatic system): 2 people, 8.70%
Conjunctivitis (pink eye): 2 people, 8.70%
Oedema Peripheral (superficial swelling): 1 person, 4.35%
Constipation: 1 person, 4.35%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 1 person, 4.35%
Breast Cancer: 1 person, 4.35%
Cancer Pain: 1 person, 4.35%
Central Nervous System Lymphoma (cancer of central nervous system forms in lymph tissue): 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Cyclophosphamide and have Ulcerative keratitis?

- Check whether Ulcerative keratitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cyclophosphamide:

Cyclophosphamide (185,240 reports)

Browse all side effects of Cyclophosphamide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ulcerative keratitis:

Ulcerative keratitis (295 drugs)

Browse all the conditions that are associated with Ulcerative keratitis:

Ulcerative keratitis (743 conditions)

Related publications that referenced our studies

Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .
Hu P, Lu L, Hu B, Deng F, Fei WJ, "Cyclophosphamide‐Induced Hypertensive Encephalopathy in a Young Girl With Lupus", The Journal of Clinical Hypertension, 2012 Apr .

How the study uses the data?

The study uses data from the FDA. It is based on cyclophosphamide (the active ingredients of Cyclophosphamide) and Cyclophosphamide (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.