Cymbalta and Blunted affect - a phase IV clinical study of FDA data

Summary:

Blunted affect is reported as a side effect among people who take Cymbalta (duloxetine hydrochloride), especially for people who are female, 40-49 old, have been taking the drug for 1 - 2 years also take Neurontin, and have Pain.

The phase IV clinical study analyzes which people have Blunted affect when taking Cymbalta. It is created by eHealthMe based on reports of 145,249 people who have side effects when taking Cymbalta from the FDA, and is updated regularly.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,973 Cymbalta users. Check the latest studies of Cymbalta.

What is Blunted affect?

Blunted affect (lack of emotional reactivity) is found to be associated with 96 drugs and 214 conditions by eHealthMe. Check the latest studies of Blunted affect.

On Jul, 06, 2026

145,249 people reported to have side effects when taking Cymbalta.
Among them, 22 people (0.02%) have Blunted affect.

Among these 22 people:

How long have people been on Cymbalta when they have Blunted affect? *

What is the gender of people who have Blunted affect when taking Cymbalta? *

female: 81.82 %
male: 18.18 %

What is the age of people who have Blunted affect when taking Cymbalta? *

What are other drugs people take besides Cymbalta? *

What are other side effects people have besides Blunted affect? *

Fatigue (feeling of tiredness): 5 people, 22.73%
Suicidal Ideation: 5 people, 22.73%
Diarrhea: 4 people, 18.18%
Drug Withdrawal Syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation): 4 people, 18.18%
Insomnia (sleeplessness): 4 people, 18.18%
Confusional State: 4 people, 18.18%
Feeling Abnormal: 3 people, 13.64%
Agitation (state of anxiety or nervous excitement): 3 people, 13.64%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 3 people, 13.64%
Drug Ineffective: 3 people, 13.64%

What are the existing conditions these people have? *

Pain: 5 people, 22.73%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 2 people, 9.09%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 9.09%
Stress Urinary Incontinence (leak urine with things like coughing, sneezing or exercise): 1 person, 4.55%
Sleep Disorder: 1 person, 4.55%
Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 1 person, 4.55%
Neuralgia (pain in one or more nerves): 1 person, 4.55%
Insomnia (sleeplessness): 1 person, 4.55%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Cymbalta and have Blunted affect?

- Check whether Blunted affect is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cymbalta:

Cymbalta (154,973 reports)

Browse all side effects of Cymbalta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Blunted affect:

Blunted affect (96 drugs)

Browse all the conditions that are associated with Blunted affect:

Blunted affect (214 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on duloxetine hydrochloride (the active ingredients of Cymbalta) and Cymbalta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.