Rexulti and Flonase drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rexulti (brexpiprazole) and Flonase (fluticasone propionate). Common drug interactions include metabolic encephalopathy among females and swollen tongue among males.

The phase IV clinical study analyzes what interactions people have when they take Rexulti and Flonase. It is created by eHealthMe based on reports of 98 people who take the same drugs from the FDA, and is updated regularly.

What is Rexulti?

Rexulti has active ingredients of brexpiprazole. It is often used in major depression. eHealthMe is studying from 13,394 Rexulti users. Check the latest studies of Rexulti.

What is Flonase?

Flonase has active ingredients of fluticasone propionate. It is often used in allergies. eHealthMe is studying from 75,441 Flonase users. Check the latest studies of Flonase.

On Jul, 06, 2026

98 people who take Rexulti and Flonase together, and have interactions are studied.

What are the common drug interactions of Rexulti and Flonase, by gender? *:

female:

Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy)
Migraine (headache)
Mobility decreased (ability to move is reduced)
Myasthenia gravis (a chronic condition that causes muscles to tire and weaken easily)
Oesophageal ulcer (ulcer of oesophagus)
Polycythaemia (proportion of blood volume that is occupied by red blood cells increases)
Retinal vasculitis (a sight-threatening inflammatory eye condition that involves the retinal vessels)
Road traffic accident
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Anxiety

male:

Swollen tongue (swelling of tongue)
Dizziness
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Localised infection (infection at the single location)
Lung disorder (lung disease)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Pain in extremity
Paralysis

What are the common drug interactions of Rexulti and Flonase, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Akathisia (a movement disorder characterized by a feeling of inner restlessness)
Cough
Fatigue (feeling of tiredness)
Growing pains (child sometimes wake up crying in the middle of the night complaining of throbbing leg pain)
Hypersensitivity
Insomnia (sleeplessness)
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Nasopharyngitis (inflammation of the nasopharynx)
Pneumonia
Restlessness (not able to rest)

30-39:

Retinal vasculitis (a sight-threatening inflammatory eye condition that involves the retinal vessels)
Suicidal ideation
Swollen tongue (swelling of tongue)
Visual impairment
Injection site bruising
Injection site mass
Injection site pain
Injection site urticaria (rash of round, red welts on the skin at injection site)
Allergy to animal
Confusional state

40-49:

Alopecia (absence of hair from areas of the body)
Hair colour changes
Hair disorder
Anxiety
Asthma
Depression
Dizziness
Facial pain
Fibula fracture
Headache (pain in head)

50-59:

Dyspnoea (difficult or laboured respiration)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Tardive dyskinesia (a disorder that involves involuntary movements)
Blood glucose fluctuation
Depression
Fatigue (feeling of tiredness)
Nausea (feeling of having an urge to vomit)
Nocturia (the need to get up in the night to urinate)
Obesity (having too much body fat)
Osteoporosis (bones weak and more likely to break)

60+:

Cough
Dizziness
Rash
Abdominal pain lower
Arthralgia (joint pain)
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Diarrhoea
Dysphonia (speech disorder attributable to a disorder of phonation)
Impaired work ability

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 47 people, 47.96%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 20 people, 20.41%
Depression: 14 people, 14.29%
Stress And Anxiety: 10 people, 10.20%
Drowsiness: 10 people, 10.20%
Immunodeficiency Common Variable: 7 people, 7.14%
Hypersensitivity: 5 people, 5.10%

* Approximation only. Some reports may have incomplete information.

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