Cymbalta and Water retention - a phase IV clinical study of FDA data

Summary:

Water retention is reported as a side effect among people who take Cymbalta (duloxetine hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Celebrex, and have Nausea and vomiting.

The phase IV clinical study analyzes which people have Water retention when taking Cymbalta. It is created by eHealthMe based on reports of 145,249 people who have side effects when taking Cymbalta from the FDA, and is updated regularly.

What is Cymbalta?

Cymbalta has active ingredients of duloxetine hydrochloride. It is often used in depression. eHealthMe is studying from 154,972 Cymbalta users. Check the latest studies of Cymbalta.

What is Water retention?

Water retention is found to be associated with 2,092 drugs and 2,457 conditions by eHealthMe. Check the latest studies of Water retention.

On Apr, 13, 2026

145,249 people reported to have side effects when taking Cymbalta.
Among them, 838 people (0.58%) have Water retention.

Among these 838 people:

* Approximation only. Some reports may have incomplete information.

Do you take Cymbalta and have Water retention?

- Check whether Water retention is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Cymbalta:

Cymbalta (154,972 reports)

Water retention treatments and more:

Water retention (79,658 reports)

How severe was Water retention and when was it recovered:

Water retention in Cymbalta

Expand to all the drugs that have ingredients of duloxetine hydrochloride:

Water retention and drugs with ingredients of duloxetine hydrochloride (1,016 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Cymbalta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Water retention:

Water retention (2,092 drugs)

Browse all the conditions that are associated with Water retention:

Water retention (2,457 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on duloxetine hydrochloride (the active ingredients of Cymbalta) and Cymbalta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.